Dr. Morgan Flashcards
(245 cards)
Define Counselling
Counselling is a process aimed at influencing individuals’ knowledge about their health and healthcare with a purpose to not only inform but also to change behaviour
Principles of counselling (hint: 7)
Principle of acceptance
Principle of communication
Principle of empathy
Principle of non-judgemental attitude
Principle of confidentiality
Principle of individuality
Principles of non-emotional involvement
The most common sickle cell syndromes (i.e., genotypes) are (hint: 3)
Sickle Cell Anaemia - 65%
Hemoglobin SC disease - 25%
Hemoglobin S Beta Thalassemia,
Some people with sickle cell trait can show the hematological abnormalities of sickle cell syndrome, T/F
FALSE
Sickle trait not associated with any hematological abnormalities
Sickle cell disease is the most common inherited blood disorder, T/F
TRUE
Male to female ratio of SCD IS 1:2, T/F
FALSE
Male / Female 1:1
Composition of Adult hemoglobin A2 is ________
2-alpha chains & 2-delta chains
There are 6 different globin chains, name them
( i ) Alpha with 141 a.a ( ii ) Beta ( iii ) Gamma ( iv) Delta
(v) Epsilon ( vi) Zeta All with 146 a.a
In HbS there is substitution of Thymine for Adenine in the 6th codon of beta chain, T/F
TRUE
The loss of _______ is central to the pathophysiology of sickle cell disease
red blood cell elasticity
Sickle cells only function/last for __ to __ days
10 - 20 days
Clinical features of Sickle anemia varies among patients, T/F
TRUE
The earliest clinical feature of sickle cell anemia is ______
Dactylitis- painful swellings of the hands and feet
The anemia in SCD is microcytic hypochromic, T/F
FALSE
Normocytic normochromic anemia (Hall mark on FBC)
The average Hb conc. in SCD is ______
8g/dL
Howell-Jolly bodies and Paperiheimer bodies on blood smear of SCD patient reflects ______
Functional asplenia
Prominent blood smear features of sickle cell disease (hint: 6)
Sickled cells, target cells and ovalocytes.
Polychromasia, basophilic stippling, and normoblasts are prominent
WBC count increases in vaso-occlusive crises state, T/F
TRUE
Platelet aggregation is increased in SCD, T/F
FALSE
Platelet aggregation is decreased, the likely result of in vivo platelet activation
Platelet count is decreased in SCD, T/F
FALSE
The platelet count is increased (approximately 440 × 109/L), reflecting reduced or absent splenic sequestration
Total platelets are decreased during vaso-occlusive crises, T/F
TRUE
The level of _______ indicates the severity of bone crises in SCD
Serum alkaline phosphatase
Gold standard for diagnosing SCD is
Hb Electrophoretic or chromatographic separation of haemoglobins in haemolysates prepared from peripheral blood
Lab tests to diagnosis of SCD (hint: 3)
- Haemoglobin solubility test
- Sickling test
- Hb Electrophoretic or chromatographic separation of haemoglobins in haemolysates