Droperidol Flashcards
What is the mechanism of action for Droperidol?
●Droperidol is an antipyschotic. It blocks Dopamine and Alpha receptors in the CNS causing…
-Sedation.
-A reduction in agitation/state of mental detachment.
-Antiemetic action.
What are the indications for Droperidol?
●Patients aged 12 or over with acute behavioral disturbance causing mid to moderate risk to safety when Olanzapine has not been administered or is ineffective.
●Moderate to severe pain despite opiate analgesia and ketamine is not appropriate, associated with…
-chronic or complex pain
-chronic use of opiates
-severe headache
severe pain with agitation
-pain with severe nausea/vomiting.
●The management of agitation or pain that does not respond to an opiate during end of life care.
●Nausea/vomiting that persists despite Ondansetron administration, or for motion sickness.
What are the contraindications for Droperidol?
●Known severe allergy.
●Aged less than 12 years old.
●Pregnancy- analgesia, nausea/vomiting.
What are the cautions for Droperidol?
●Altered level of consciousness. (Will increase/prolongs the effects.)
●Parkinson’s disease. (Risk of worsening the movement disorder.)
●Concurrent administration of Midazolam and Ketamine. (Will increase/prolong effects.)
●Aged 75 or over, particularly if frail. (Increases/prolongs effects.)
●Signs of shock. (May make shock worse.)
What are the adverse effects of Droperidol?
●Hypotension. May occur if a large IV dose is administered rapidly.
●Sedation. Concurrent administration with other sedative drugs such as Olanzapine or Midazolam will increase effects.
What is the IV dose for Droperidol with acute behavioral disturbance?
10mg but reduce to 5mg if a caution is present.
(Dilute to 10mls and administer over 1-2mins.)
Dose may be repeated once after 20 minutes.
What is the IM dose for Droperidol with acute behavioral disturbance?
10mg but reduce to 5mg if a caution is present.
(Non diluted. Into lateral thigh.)
Dose may be repeated once after 20mins.
What is the IV dose of Droperidol for analgesia?
1.25mg IV for an adult but reduce to 0.625mg if a caution is present
(Use 2.5mg/1ml ampule dilute to 4ml and discard 2ml leaving 1.25mg/2ml. If caution is present administer 0.625mg/1ml.)
The dose is not repeated.
What is the IV dose of Droperidol for nausea/vomiting?
0.625mg IV for an adult. (Dilute 2.5mg to 4ml making 0.625mg/ml.)
The dose is not repeated.
What is the IM dose of Droperidol for nausea/vomiting?
0.625mg IM for an adult undiluted.
The dose is not repeated.
What is the dose of Droperidol for end of life care?
2.5mg IV/IM/SC
The dose can be repeated as required.
