Tranexamic Acid

Question 1

What is the mechanism of action of TXA?

Answer 1

●Antifibrinolytic. Blocks the version of plasminogen to plasmin which reduces fibrinolysis (breakdown of blood clots) and bleeding.

Question 2

What are the indications of TXA?

Answer 2

●Hypovolaemia from uncontrolled bleeding.
●Postpartum Haemorrhage.
●Crush injury.
●Severe bleed enough to cause hypovolaemia requiring sodium chloride IV.
●Cardiac Arrest secondary to trauma.

Question 3

What are the contraindications of TXA?

Answer 3

●Known severe allergy.
●Trauma greater than 3 hours old.

Question 4

What are the cautions for TXA?

Answer 4

There are none.

Question 5

What are the adverse effects for TXA?

Answer 5

There are none.

Question 6

What is the preparation of TXA for an adult?

Answer 6

Draw up the 1g/10ml ampoule and administer IV undiluted over 1-2 minutes. Flush with 10ml of saline.

Question 7

What is the onset time of TXA?

Answer 7

30-60 minutes.

Question 8

What is the duration of effect of TXA?

Answer 8

8 hours.