Drug Interactions

Question 1

CYP450 Enzyme Inhibitors
- SICKFACES.COM GAVID

Answer 1

Sodium Valproate
Isoniazid
Cimetidine
Ketoconazole

Fluconazole
Alcohol
Chloramphenicol
Erythro/clarithromycin
Sulfonamides (trimethoprim)

Ciprofloxacin
Omeprazole
Metronidazole

Grapefruit juice
Amiodarone
Verapamil
Itraconazole
Diltiazem

Question 2

CYP450 Enzyme Inducers
- SCRAP GPs

Answer 2

St John’s wort
Carbamazepine
Rifampicin and Rifabutin
Alcohol
Phenytoin

Griseofulvin
Phenobarbital
Sulphonylureas

Question 3

CYP450 Enzyme Substrates
- W.COAT

Answer 3

Warfarin
Corticosteroids
Oral contraceptives
Aminophylline/ theophylline
Statins
TCAs

Question 4

Anti-muscarinic medications

Answer 4

Oxybutinin
Solifenacin
Tolterodine

Hyoscine
Gycopyrronium

Tiotropium
Ipratropium

Question 5

antimuscrainic side effects

Answer 5

Blurred vision
Urinary retention
Constipation
Dry mouth
+
Drowsiness
Headache
Glaucoma

Question 6

Drugs associated with increase risk of bleeding

Answer 6

Corticosteroids
Carbocistein
DOACs
Warfarin
NSAIDs
SSRIs

Question 7

Symptoms of serotonin syndrome

Answer 7

1. Altered mental state
   - agitation
   - anxiety
   - confusion
2. Autonomic hyperactivity
   - hyperthermia
   - tachycardia
   - hypertension
3. Neuromuscular hyperactivity
   - rigidity
   - tremor

Question 8

medication associated with serotonin syndrome

Answer 8

Antidepressants
- SSRIs and SNRIs
- TCAs
- MAOI

Pain meds
- Tramadol
- opioids
- methadone

Lithium
Ondansetron

St John’s wort

Linezolid