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ESAR 3.4 Exam 2 > Drug Interactions (Quiz) > Flashcards

Drug Interactions (Quiz) Flashcards

(147 cards)

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1
Q

Ramipril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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2
Q

Quinapril

A

Antacid: Reduce absorption

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3
Q

Lisinopril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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4
Q

Enalapril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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5
Q

Benazepril

A

Neprilysin inhibitors (sacubitril): increased risk of angioedema

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6
Q

Doxazosin

A

CYP3A4 inhibitor: decreased metabolism

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7
Q

Hydrochlorothiazide

A

Dofetilide: Increased risk of QTc prolongation

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8
Q

digoxin

A

P-glycoprotein inhibitor

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9
Q

Verapamil

A

Moderate CYP3A4 inhibitor

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10
Q

Diltiazem

A

Strong CYP3A4 inhibitor

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11
Q

Gemfibrozil

A

HMG-CoA Reductase Inhibitors: increased risk of myopathy or rhabdomyolysis

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12
Q

Fenofibrate

A

Warfarin: increased risk of bleeding

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13
Q

Ezetimibe

A

Warfarin: increased risk of bleeding

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14
Q

Simvastatin

A

Major CYP3A4 substrate

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15
Q

Rosuvastatin

A

Antacids: reduce absorption

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16
Q

Pravastatin

A

Bile acid-binding resins: reduce absorption

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17
Q

Lovastatin

A

Fibrate/niacin: Increased risk of myopathy or rhabdomyolysis

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18
Q

Olopatadine

A

No clinically significant interactions

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19
Q

Loratadine

A

CNS Depressants: increased risk of sedation

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20
Q

Promethazine

A

CNS Depressants: increased risk for sedation

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21
Q

Meclizine

A

CNS depressants: increased sedation

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22
Q

nystatin

A

No clinically significant interactions

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23
Q

Ketoconazole

A

No major drug interactions

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24
Q

Naproxen

A

Anticoagulants and antiplatelets: increased bleeding risk

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25
Meloxicam
Warfarin: increased risk of bleeding
26
Ibuprofen
Antihypertensives: decreased efficacy
27
Diclofenac
Warfarin: increased risk of bleeding
28
Omeprazole
Clopidogrel: inhibits metabolism of clopidogrel to active form
29
Lansoprazole
Clopidogrel: Co-administration with Prevacid® inhibits metabolism of clopidogrel to active form
30
Ranitidine
pH-dependent drugs: ranitidine reduces absorption
31
warfarin
NSAIDs: increased risk of bleeding
32
enoxaparin
NSAIDs: may increase the chance of bleeding
33
Rivaroxaban
Antiplatelet agents: increased bleeding risk
34
Dabigatran
P-gp inducers: avoid coadministration with Pradaxa
35
Ticagrelor
NSAIDs: increased bleeding risk
36
Clopidogrel
CYP2C19 inhibitors: decreased clopidogrel activation
37
Folic acid
none
38
Levalbuterol
Non-selective beta blockers: decreased effectiveness of Xopenex
39
Albuterol
Non-selective beta blockers: decreased albuterol effect
40
Oseltamivir
Live influenza vaccine: administer 2 weeks prior or 48 hours after
41
Nitroglycerin
Phosphodiesterase inhibitors: excessive hypotension
42
tiotropium
Anticholinergics: additive effect
43
fluticasone+salmeterol
Non-selective beta blockers: decreased effectiveness of salmeterol
44
Budesonide+formoterol
Non-selective beta blockers: decreased effectiveness of formoterol
45
Prednisone
Fluoroquinolones: Increased risk of tendon rupture
46
Methylprednisolone
Fluoroquinolones: Increased risk of tendon rupture
47
Mometasone
CYP3A4 inducers/inhibitors: decreased/increased plasma levels of Asmanex
48
Levothyroxine
warfarin, al, ca, mg, fe
49
Risedronate
Aluminum, calcium, magnesium, iron
50
Alendronate
mg, ca, al, fe
51
Sildenafil
alpha blockers and nitrates: hypotension
52
metronidazole
ethanol: disulfiram like reaction; warfarin: increased bleeding risk
53
Minocycline
Aluminum, calcium, magnesium, iron: decreased minocycline absorption due to chelation
54
Penicillin
Probenecid: increases penicillin concentrations
55
Clarithromycin
QTC interval prolonging agents: additive effects on internal; major substrates and inhibitors of cyp3a4
56
azithromycin
QTC interval prolonging agents: additive effects on internal; major substrates and inhibitors of cyp3a4
57
Vardenafil
Nitrates and Alpha-blockers
58
tadalafil
Nitrates and Alpha-blockers
59
Humalog (lispro)
Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia
60
Novolog (aspart)
Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia
61
Lantus (glargine)
Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia
62
Levemir (detemir)
Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia
63
Glimepiride
Beta-blockers: altered glucose metabolism causing increased risk of hypoglycemia, masks symptoms of hypoglycemia
64
Saxagliptin
Major CYP3A4 substrate
65
Metformin
Iodine
66
tamsulosin
BBs, CCBs: increased risk of hypotension
67
Tolterodine
QTc interval-prolonging agents: additive effects on QTc interval
68
Solifenacin
QTc interval-prolonging agents: additive effects on QTc interval
69
Nabumetone
Anticoagulants and antiplatelets: increased bleeding risk; Antihypertensives: decreased efficacy
70
celecoxib
Antihypertensives: decreased efficacy; Anticoagulants and antiplatelets: increased bleeding risk
71
Baclofen
CNS depressants
72
Cyclobenzaprine
Anticholinergic drugs
73
Methocarbamol
CNS depressants
74
Tizanidine
CNS depressants
75
Fentanyl
Benzodiazepines
76
Tramadol
CYP2D6 inhibitors and inducers
77
Morphine
CNS depressants
78
Methadone
QTc prolonging drugs
79
Oxycodone
Benzodiazepines
80
Codeine / Acetaminophen
CYP2D6 inhibitors and inducers
81
Percocet (Oxycodone/APAP)
CYP3A4 inducers and inhibitors
82
Buprenorphine + Naloxone
Opioid antagonists/agonists
83
Gabapentin
CNS depressants
84
Lamotrigine
Estrogen based contraceptives, enzyme inducers rifampin and carbamazepine
85
Levetiracetam
None
86
Divalproex
Carbapenems
87
Phenytoin
CYP3A4 substrates
88
Pregabalin
CNS depressants
89
Topiramate
Carbonic anhydrase inhibitors
90
Glipizide
Fluoroquinolones
91
Glyburide
Beta-blockers
92
Nitrofurantoin
Norfloxacin
93
Valacyclovir
Varicella and zoster virus vaccine
94
Ropinirole
CYP1A2 inducers
95
Memantine
none
96
Sumatriptan
Monoamine oxidase inhibitors
97
Tylenol
Warfarin
98
Risperidone
CYP2D6 inhibitors
99
Amitriptyline
CYP2D6 inhibitors
100
Mirtazapine
CYP3A4 inhibitors and inducers
101
Quetiapine
CYP3A4 inducers and inhibitors
102
Olanzapine
CYP1A2 inducers and inhibitors
103
Aripiprazole
Dopamine agonists
104
Phenelzine
Sympathomimetics
105
Bupropion
CYP2D6 inhibitors
106
Paroxetine
MAOIs
107
Escitalopram
Antiplatelet drugs
108
Venlafaxine
Anticoagulants
109
Citalopram
CYP3A4 inhibitors
110
Duloxetine
MAOIs
111
Sertraline
Anticoagulants
112
Methylphenidate
MAOIs
113
Amphetamine
MAOIs
114
Phentermine
MAOIs
115
Lisdexamfetamine
MAOIs
116
Zolpidem
CNS depressants
117
Temazepam
Oxycodone
118
Trazodone
Linezolid
119
Buspirone
MAOIs
120
Lorazepam
Valproate
121
Alprazolam
CYP3A4 inhibitors
122
Benztropine
Tiotropium (anticholinergic)
123
Diazepam
CNS depressants
124
Clonazepam
CYP3A4 inhibitors
125
Ferrous sulfate
Bisphosphonates
126
Etanercept
Immunosuppressants
127
Esomeprazole
Drugs that require acidic pH for absorption (eg. atazanavir)
128
Adalimumab
Live vaccines
129
Protonix
Clopidogrel
130
Tretinoin
Photosensitizing agents
131
Hydroxychloroquine
Mefloquine
132
Ondansetron
CYP3A4 inducers
133
Allopurinol
Pegloticase
134
Metoclopramide
Dopamine agonists
135
Methotrexate
NSAIDs
136
Travoprost
None
137
Mupirocin
None
138
Latanoprost
None
139
Phenazopyridine
None
140
Dicyclomine
Potassium citrate
141
hydrocodone/acetaminophen
CNS depressants
142
Darunavir
Lovastatin
143
bictegravir/emtricitabine/tenofovir alafenamide
Calcium supplements
144
Symtuza
Carbamazepine
145
Genvoya
Mometasone
146
Dolutegravir
Dofetilide
147
Odefsey
Proton pump inhibitors

ESAR 3.4 Exam 2 (5 decks)

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