List the avermectins. To what category of drugs do avermectins belong?
ivermectin
selamectin
doramectin
eprinomectin
Belong to the macrolides/macrocyclic lactones.
List the milbemycins. To what category of drugs do milbemycins belong?
milbemycin oxime
moxidectin
Belong to the macrolides/macrocyclic lactones.
What is the mechanism of action for macrolides/macrocyclic lactones?
Hold open chloride channels on muscles cells, by bonding with the glutamate receptors that controls the chloride channel. Holding the channels open means that chlorides flow into the cell, making it more negative and thus harder to depolarize. When the muscle cells can’t depolarize, there is muscle paralysis. A parasite that can’t swallow or use muscles for movement then starved to death and/or gets flushed out by not being able to swim upstream in the GI tract.
What two groups of drugs are considered macrolides/macrocyclic lactones?
avermectins
milbemycins
List brand names for ivermectin in dogs.
Dogs- Heartgard Plus, Iverhart Max
List brand names for ivermectin in cats.
Cats- Heartgard (for cats)
List brand names for ivermectin in horses.
Horses- Zimecterin, Eqvalan
List brand names for ivermectin in cattle.
Cattle- Ivomec
What is the spectrum of activity for ivermectin?
Ivermectins are anti-nematodal (anti-roundworms), including heartworms.
How is selamectin administered?
Topically
What is the brand name for selamectin?
Revolution
