Drug monitoring

Question 1

Name 4 side effects of ACEi

Answer 1

Hypotension
Dry cough
Hyperkalaemia
Renal impairement

Question 2

What monitoring is required for ACEi

Answer 2

U+E
eGFR
BP

Question 3

What is the frequency of ACEi monitoring

Answer 3

1-2 weeks from starting
sooner in high risk patients

Question 4

Name 4 side effects of Amiodarone

Answer 4

Hyper/Hypo - thyroidism
Pulmonary toxicity
Raised serum transaminases
Grey skin discolouration
Phototoxicity

Question 5

What monitoring is required for Amiodarone

Answer 5

TFT
LFT
U+E - Especially K+
Advise patients on sunbed risk
CXR - pre treatment

Question 6

What is the frequency of monitoring for Amiodarone

Answer 6

Every 6m

Need to continue monitoring after stopping - long half-life

Question 7

What should patients on azathioprine be advised to report

Answer 7

bone marrow suppression symptoms
- unexplained bruising / bleeding
- infection
- new onset jaundice

Question 8

Name 4 adverse effects of carbimazole

Answer 8

Neutropenia
Agranulocytosis
Rash
Pruritus

Question 9

What is the effect of alcohol on theophylinne

Answer 9

Reduces clearance

Question 10

What factors increase risk of myopathy in patients taking statins

Answer 10

FHx
Hx muscular disorder
Elderly
High alcohol intake

Question 11

If high risk of myopathy in patients on statins what in required

Answer 11

Baseline CK
+ Baseline LFT