General notes Flashcards

1
Q

Explain risks of breast cancer in woman taking HRT

A

Low with oestrogen only

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2
Q

Name risks associated with HRT

A

Breast cancer
Endometrial cancer
VTE
Stroke / CVD

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3
Q

Who do the risks of HRT not apply to

A

Women < 50 years old

No increased CVD risk with oestrogen only HRT

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4
Q

Who do you not give HRT to

A

Women > 60 years old

Risks outweigh benefits

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5
Q

Name 5 CI to HRT

A

Undiagnosed endometral bleeding
Endometrial cancer
Breast cancer
Uncontrolled HTN
VTE
Active angina or MI
Pregnancy

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6
Q

How long is the Mirena coil licensed for endometrial protection

A

4 years

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7
Q

When is the risk of stroke / CAD increased

A

If taken > 10 years after menopause - combined

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8
Q

How is the risk of breast cancer affected by stopping HRT

A

Declines once stopped and normal in 5 years

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9
Q

Name 5 adverse effects of antimuscarinics

A

Confusion
Dry mouth
Tachycardia
Dilated pupil
Loss of accommodation

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10
Q

What occurs if Methotrexate and Trimethoprim are co-prescribed

A

Pancytopenia
Neutropenic sepsis

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11
Q

Name the presentation and ECG signs for Hypercalcameia

A

Renal stones
Bone pain
Abdominal groans
Psychiatric overtones

Short QT interval

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12
Q

What medications should be cautioned in patients taking Methotrexate

A

PPI
NSAIDs
Ibuprofen - risk of nephrotoxicity

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13
Q

Name the adverse effects of anticholinergics

A

cosntipation
dry mouth
blurred vision
urinary retention

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14
Q

Name 3 anticholinergic drugs

A

Oxynutinin
Atropine
Tiotropium

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15
Q

Name 3 drugs that effect lithium excretion

A

ACEi
Diuretics
NSAIDs

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16
Q

Name 5 drugs causing agranulocytosis

A

Carbamazepine

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17
Q

Name 5 drugs causing agranulocytosis

A

Carbamazepine
clozapine
colchicine
carbimazole

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18
Q

Which opioids are safe in CKD

A

Oxycodone
alfentanil
fentanyl

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19
Q

Name 5 drugs that cause C.diff infection

A

PPI
Clindamycin
Co-amox
CIprofloxacin
Cephalosporin

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20
Q

Name drugs that prolong QTc

A

A - Antidepressants (SSRI / TCA)
A - Antipsychotics
A - Antibiotics
A - Anti arrhythmics
A - Antifungals
A - Antiemetics
D - Diuretics

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21
Q

What is the minimum treatment length with steroids to require prophylactic bisphosphonates

A

3 months

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22
Q

How do you assess the response to Abx in penumonia

A

1 - O2 stats / ABG

2 - Resp rate

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23
Q

What are the contraindications to the COCP

A

Breastfeeding and <6 post partum
Migraine with aura
>35 and smoking >15/day
VTE
Active cancer

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24
Q

What drugs do statins interact with

A

Macrolides
Grapefruit juice

25
Q

Which drugs cause urinary retention

A

Opiods
NSAIDs
Anticholinergics
Antihistmaies
TCA
General anaesthetics
Alpha adrenoreceptors agonists
NSAIDs
CCB
Alcohol

26
Q

What are the risks assosciated with PPIs

A

Low sodium
Low magnesium
Osteoperosis
fracture
Micoscopic colitis
C.difficile

27
Q

What drugs should you stop during sick day rules

A

ACE
ARB
Diuretics
NSAIDs
SGLT-2i
Metformin

28
Q

What do you monitor for the adverse effects of ACEi

A

Serum Cr

29
Q

Which group of drugs should be avoided in severe PVD - critical ischaemia

A

ACEi

30
Q

Name 5 adverse effects of statins

A

Myalgia
Myositis
Rhabdomyolysis
Headache
Sleep disturbance
GI disturbance

31
Q

Name 5 drugs causing haematemesis

A

NSAIDs - Ibuprofen
Aspirin
Bisphosphonates

32
Q

Name 2 adverse effects of aspirin use

A

Dyspepsia
IDA

33
Q

Drugs causing confusion

A

Anticholinergics - TCA
Opiates
BDZ
Antipsychotics
Antidepressants
Anti-epileptics
Antihistmaies
Digoxin
Beta blockers
Steroids
NSAIDs

34
Q

Drugs increasing falls risk in elderly

A

Antidepressants - TCA / SNRI / MAOi
Opiods
Anti-epileptics
Antipsychotics
Sleeping pills
Diuretics
alpha blockers
ACEi
SU / Gliclazide - Check BM

35
Q

When should SSRIs be cautioned

A

Poorly controlled epilepsy
PUD

36
Q

What do you avoid prescribing in IHD

A

NSAIDs

37
Q

What do you avoid prescribing in IHD

A

NSAIDs
Oestrogens

38
Q

What increases the risk of Methotrexate toxicity

A

PPI

39
Q

When should you degrease the dose of SGLT-2 inhibitors

A

When eGFR decreases

40
Q

Name 4 causes of constipation

A

Antidepressants
Anticholinergics
Opioids
Antiemetics - Ondansetron

41
Q

When should a diabetic patient be prescribed antihypertensives

A

Albumin:Cr > 3 –> ACEi or ARB

42
Q

When should ACEi be avoided

A

Renal artery stenosis
PVD - Critical
eGFR < 30

43
Q

Long term treatment post ACS

A

CRABS
C - Clopidogrel
R - Ramipril
A - Aspirin
B - Beta blocker
S - Statin

44
Q

Name 5 drugs that worsen seizure control

A

Alcohol
Tramadol
Lithium
Clozapine
Ciprofloxacin
Aminophylline
Mefanamic acid

45
Q

Name 4 drugs to avoid in Heart failure

A

Pioglitazone
Verapamil
NSAIDs
Steroids
Flecanide

46
Q

Name 4 drugs to avoid prescribing in renal failure

A

NSAIDs
ACEi
Metformin
Lithium
Digoxin

47
Q

Name 6 drugs to avoid prescribing in pregnancy

A

Tetracycline
Amingoglycosides
Sulphonamides / Trimethorpim
Quinolones
Warfarin
Sulphonyurea
Statins
Cytotoxics

48
Q

Name 6 drugs to avoid in breastfeeding patients

A

Ciprofloxacin
Sulpjonamides
Lithium
BDZ
Aspirin
Carbimazole
MXT
SU
Amiodarone

49
Q

What effect do quinolones have on the heart

A

Lengthen QT interval

50
Q

What condition are aminoglycosides CI in

A

Myasthenia gravis

51
Q

What is the management of PVD

A

Antiplatelet + Statin (high dose)

52
Q

What is the baseline monitoring and treatment moniotring required for aminophylline

A

Baseline - LFT

Treatment - U+E

53
Q

In what patients should you prescribe with caution / are CI to NSAIDs

A

Asthma
AKI / CKD
Elderly
Gastric ulcers
CCF

54
Q

When should you take:
- ACEi

  • Loop diuretics
A

Morning - avoid postural hypotension

Evening

55
Q

What is a side effect of a PPI

A

Gynaecomastia

56
Q

When is cyclizine CI

A

HF

57
Q

When is metocloprmaide CI

A

PD
Post gastrectomy
Bowel obstruction

58
Q

Management of acute asthma in the community

A

For an adult, give 4 puffs initially, followed by 2 puffs every 2 minutes according to response, up to 10 puffs.
Repeat every 10-20 minutes if clinically necessary.

For a child, give a puff every 30–60 seconds, up to 10 puffs.