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Flashcards in Drug review Deck (59)
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1

Epinephrine mech?

activate a1, a2, B1, B2, B3 [B2 > a1]

2

Epinephrine effect on:
HR
SBP
DBP
MAP
TPR

in low dose vs normal dose

Low dose → decrease diastolic and mean BP
o Increase HR/SBP/slightly MAP and decrease TPR/DBP

Normal dose
o Increase all HR/SBP/DBP/MAP/TPR

3

Norepinephrine mech?

activates a1, a2, B1 [NOT B2]

4

Norepinephrine effect on:
HR
SBP
DBP
MAP
TPR

increase DBP/MAP/SBP/TPR; decrease HR
o Strong baroreceptor decreases HR
o Increases BP more than Epi due to lack of B2

5

Use of norepinephrine?

cardiogenic shock, septic/hypovolemic shock

6

adverse of norepi?

severe hypertension

7

Isoproterenol mech?

activates B1/B2/B3 [not As]

B agonist

8

Isoproterenol effect on:
HR
SBP
DBP
MAP
TPR

decrease DBP/MAP/TPR; increase SBP slightly/HR
o Biggest increase HR b/c direct same direction as reflex

9

Dobutamine mech?

selective B1 agonist

10

Dobutamine effect?

increase HR and contractility

11

Dopamine mech?

low dose = D1
moderate = D1 + B1
high = D1 + B1 + a1

12

Dopamine effect at low, medium high dose?

low = more renal flow + urine output, decrease BP a little
moderate = decrease BP a little, increase HR/CO, no change in TPR
high = increase BP, a1 effect outweighs D1 effect

13

Fenoldopam mech?

selective D1 agonist

14

Fenoldopam effect?

decrease BP --> used to treat severe HTN

15

Albuterol Mech?

selective B2 agonist

16

Albuterol effect?

vasodilate + bronchodilate + increase HR

17

Side effects/adverse of albuterol?

tachycardia, N/V, hypokalemia, hypotension

18

Phenylephrine mech?

a agonist, slightly selective for a1

19

Clonidine mech?

a2 agonist = sympatholytic adrenergic agonist

20

What is action of tyramine?

NE releaser = indirect sympathomimetic

in aged cheese/meat/fish/wine

avoid with MAO inhibitor

21

What is mech of propanolol?

non-selective B blocker
also a class II anti-arrhythmic

22

What is use of B blockers?

- angina, SVT, slowing ventricular rate during AFib/flutter
- HTN
- MI

23

What is mech of nadolol?

non-selective B blocker

24

What is mech of metoprolol?

selective B1 blocker

25

What is mech of atenolol?

selective B1 blocker

26

What is mech of bisoprolol?

selective B1 blocker

27

What is mech of action of pindol?

partial B1/B2 agonist

- in absence of normal physiologic agonist it is an agonist
when high sympathetic drive --> its a beta antagonist

28

What is black box warning with B blockers?

don't withdraw quickly b/c upregulated B receptors cause unsafe increase in HR and contractility

29

What B blocker does not have black box warning?

pindol

30

WHat is mech carvedilol?

antagonist at B1, B2
partial antagonist at a1