Lec 27 Diseases of the Aorta Flashcards Preview

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Flashcards in Lec 27 Diseases of the Aorta Deck (46)
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1

What is a true aneurysm vs false aneurysm?

true = dilatation of all 3 layers of aorta [>50% increase in diameter]

false = rupture through intimal and medial layers contained by adventitia or perivascular thrombus/clot

2

What is fusiform vs saccular aneurysm? which is more common?

fusiform = more comm, symmetrical on both side
saccular = localized just one side

3

What is primary pathogenesis of ascending thoracic aortic aneurysm?

cystic medial necrosis/degeneration = degeneration and fragmention of elastic fibers

normal media components replaced with acellular stuff [collagen/mucoid material]

4

What are some etiologies of cystic medial necrosis causing ascending aortic aneurysm?

- occurs with aging due to hypertension
- or w/ disorders that affect connective tissue
--- Marfan
--- Loeys-Dietz syndrome
--- Ehlers-Danlos syndrome
- or bicuspid aortic valve

5

What causes marfan?

missense mutation in fibrillin gene --> impaired formation of elastin

6

What causes loeys dietz?

autosomal dom. mutation in TFG-B receptors

7

What causes ehler-danlos syndrome?

mutation in collagen

8

What is pathogenesis of anuerysms of descending thoracic and abdominal aorta?

usually due to atherosclerosis

9

What are some risk factors for descending aorta aneurysm?

- smoking
- dyslipidemia
- men
- HTN
- age [older]

== atherosclerotic risk factors

10

What is most common location of aortic aneurysm?

abdominal aorta

11

Besides the most common cystic medial necrosis and atherosclerosis, what are some other possible etiologies of aortic aneurysm?

- post-stenotic
- infection of arterial wall
- vasculitis [giant cell arteritis/takayasu arteritis]

12

What is natural history of aortic aneurysms?

expand by avg 1-4 mm/year

13

What are predictors of rate of abdominal aortic expansion?

- initial size [bigger size = faster expansion]
- active smoking
- hypertension

14

At what diameter abdominal aortic aneurysm should you call surgery? what about in marfans pt?

at 5.5 cm for normal pt; 5 cm for marfans

15

What are most common complications of abdominal aortic aneurysm?

- death
- rupture
- dissection

16

What is normal clinical presentation of aortic anuerysm?

- usually asymptomatic
- if thoracic --> may have cough/ dyspnea/ dysphagia from compression neighboring struct

- if ascending --> may have aortic regrug and symptoms of CHF

- if abdominal --> may have ab or back pain or nonspecific GI symptoms

17

How is aortic aneurysm normally discovered?

pt has chest or ab radiograph for some other reason and see dilation of vessel

18

How do you diagnose aortic aneurysm?

- chest or abdominal radiograph --> widened mediastinum

19

What is treatment for aortic aneurysm?

- reduce risk factors:
--- BBlockers to lower BP
--- smoking cessation

- once diagnosed monitor by image every 6-12 mo

20

When do you refer aortic aneurysm for repair?

based on side
>5.5 cm for abdominal aortic aneurysm OR
growth rate > 1 cm/yr

21

What is surgical treatment for aortic aneurysm?

- open surgical repair OR PCI: transfermoral stent graph repair

22

What is aortic dissection?

blood from vessel lumen passes through tear in intima into medial layer and spreads along the artery = forms a false lumen

23

What is acute intramural hematoma?

variant of aoritc dissection = hemorrhage in wall of aorta without evidence of intimal tear

24

What is a penetrating atherosclerotic ulcer?

erosion of plaque into aortic wall

25

What is an aortic rupture?

may be a complication of aortic dissection, intramural hematoma, penetrating atherosclerotic ulcer or from trauma

26

What is Stanford type A aortic dissection vs type B?

type A = involves ascending aorta [can also involve descending]

type B = involves descending aorta and DOES NOT involve ascending

27

What are the 2 postulated mech of aortic dissection?

- circumfrerential or transverse tear in intimal layer of the vessel --> blood enters media --> propagates along plane of muscle layer

OR

- rupture of vaa vasorum --> hemorrhages into the media --> forms hematoma in arterial wall --> tears through intima into vessel lumen

28

Who most commonly gets aortic dissection?

men in 60s-70s

29

What are risk factors for aortic dissection?

- hypertension
- smoking
- use of cocaine or stimulants
- connective tissue disease [marfans, ehlers danlos etc]
- congenital structural abnormality [coartcation of the aorta, abnormal aortic valve]
- inflammatory disease
- can be brought on by weight lifting/trauma

30

What part of aorta most commonly dissects?

- ascending thoracic aorta = 65%
- descending thoracic aorta = 20%