Drug rxns Flashcards Preview

Pharmacology > Drug rxns > Flashcards

Flashcards in Drug rxns Deck (57):
1

Coronary vasospasm

cocaine, sumatriptan (serotonin agonist), ergot alkaloids

2

Cutaneous flushing

"VANC"
vancomycin, adenosine, niacin, CCB

3

Dilated cardiomyopathy

doxorubicine, daunorubicin

4

TdP

class III and IA antiarrhyhmics, macrolides, antipsycotics, TCAs

5

Adrenocortical insufficiency

glucocorticoid withdrawal (creates 2ndary HPA suppression)

6

Hot flashes

tamoxifen, clomiphene

7

Hyperglycemia

"Taking Pills Necessitates Having Blood Checked"
Tacrolimus, Protease inhibitors, Niacin, HCTZ, B-blockers, Corticosteroids

8

Hypothyroidisim

lithium, amiodarone, sulfonamides

9

Acute cholestatic hepatitis, jaundice

erythromycin

10

Diarrhea

"Might Excite Colon On Accident"
Metformin, Erythromycin, Cholchicine, Orlistat, Acarbose

11

Focal/massive hepatic necrosis

"liver HAVAc"
Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen

12

Hepatitis

INH

13

Pancreatitis

"Drugs Causing A Violent Abdominal Distress"
Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

14

Pseudomembranous colitis

Clindamycin, ampicillin, cephalosporins

15

Agranulocytosis

"Drugs CCCrush Myeloblasts and Promyelocytes"
Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil

16

Aplastic anemia

"Can't Make New Blood Cells Properly"
Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

17

Direct Coombs + hemolytic anemia

Methyldopa, penicillin

18

Gray baby syndrome

Chloramphenicol (toxic accumulation of metabolites)

19

Hemolysis in G6PD deficiency

"hemolysis IS D PAIN"
INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

20

Megaloblastic Anemia

"having a blast with PMS"
Phenytoin, Methotrexate, Sulfa drugs -> all interfere with folate

21

Thrombocytopenia

heparin, cimetidine

22

Thrombotic complications

OCPs

23

Fat redistribution

"Fat PiG"
Protease inhibitor, glucocorticoids

24

Gingival hyperplasia

phenytoin, verapamil, cyclosporine, nifedipine

25

Hyperuricemia (gout)

"Painful Tophi and Feet Need Care"
Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

26

Myopathy

fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids

27

Osteoporosis

corticosteroids, heparin

28

Photosensitivity

"SAT For Photo"
Sulfonamides, Amiodarone, Tetracycline, 5-FU

29

Rash (Stevens-Johnson syndrome)

"Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin"
anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin

30

SLE-like syndrome

"having lupus is SHIPP-E"
Sulfa drugs, hydralazine, INH, Procainamide, Phenytoin, Etanercept
Also minocycline and quinidine

31

Teeth discoloration

Tetracyclines

32

Tendonitis, tendon rupture, cartilage damage

fluoroquinolones

33

Cinchonism

quinidine, quinine

34

Parkinson-like syndrome

"cogwheel rigidity of ARM"
Antipsychotics, Reserpine, Metoclopramide

35

Seizures

"with seizures, I BITE My tongue"
INH (vit b6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
Also clozapine and ciprofloxacin

36

Tardive dyskinesia

Antipsychotics, metoclopramide

37

DI

lithium, demeclocycline

38

Fanconi syndrome

expired tetracycline

39

Hemorrhagic cystitis

cyclophosphamide, ifosfamide
prevent by coadministering with mesna

40

Interstitial nephritis

methicillin, NSAIDs, furosemide

41

SIADH

"Can't Concentrate Serum Sodium"
Carbamazepine, Cyclophosphamide, SSRIs

42

Dry cough

ACEi

43

Pulmonary fibrosis

"Breathing Air Badly from Medications"
Bleomycin, Amiodarone, Busulfan, Methotrexate

44

Antimuscarinic

atropine, TCAs, H1-blockers, antipsychotics

45

Disulfiram-like rxn (increased acetaldehyde leading to n/v, headache)

metronidazole, certain cephalosporine, griseofulvin, procarbazine, 1st-gen sulfonylureas

46

Nephrotoxicity/ototoxicity

aminoglycosides, vancomycin, loop diuretics, cisplatin

47

P450 Inducers ("Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs"

Chronic alcohol use, Modafinil, St. John's wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine

48

P450 Substrates ("Always Always Always Always Think When Starting Others")

Anti-epileptics, Antidepressants, Antipsychotics, Anesthetics, Theophylline, Warfarin, Statins, OCPs

Also metronidazole

49

P450 Inhibitors ("A cute Gentleman "Cipped" Iced Grapefruit juice Quickly And Kept Munching on Soft Cinnamon Rolls")

Acute alcohol abuse, Gemfibrozil, Ciprofloxacin, Isoniazid, Grapefruit juice, Quinidine, Amiodarone, Ketoconazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir

Also omeprazole, SSRIs

50

Sulfa drugs

"Popular FACTSSS"
Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas

51

QT Prolongation

"Some Risky Meds Can Prolong QT"
Sotalol, Risperidone (antipsychotics), Macrolides, Chloroquine, Protease inhibitors, Quinidine (class Ia, also III), Thiazides

52

Hepatic granulomatosis

Methyldopa, hydralazine, quinidine

53

Pill-induced esophagitis

Tetracycline, potassium chloride, bisphosphonates

54

Cholesterol gallstone

Fibrates, octreotide, ceftriaxone

55

Cold extremities resulting in Raynaud's phenomenon

B-blockers, ergotamine

56

Gynecomastia

"Some Dope Drugs Easily Create Awkward Hairy DD Knockers"
Spironolactone, marijuana, Digitalis, Estrogen, Cimetidine, Alcohol, Heroin, Dopamine, D2 antagonists, Ketoconazole

57

Transitional cell carcinoma

"Pee SAC"
Phenacetin, Smoking, Aniline dyes, Cyclophosphamide