GI drugs Flashcards Preview

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Flashcards in GI drugs Deck (39):
1

Deferasirox (use)

Hemochromatosis

2

Deferoxamine (use)

Hemochromatosis

3

Cimetidine and other "-dine" (mechanism)

H2 blocker (reversible)

4

Cimetidine and other "-dine" (3 uses)

Peptic ulcer
Gastritis
Mild reflux

5

Cimetidine and other "-dine" (side effects)

Cimetidine only: P450 inhibitor, antiandrogenic, crosses BBB and placenta
Cimetidine and ranitidine: decreases renal excretion of creatinine

6

-prazole (mechanism)

PPI - irreversibly inhibit H+/K+ ATPase in parietal cells
So will inhibit acid secretion in response to ACh, histamine, and gastrin (unlike atropine, which only blocks ACh pathway, or H2 blockers, which only block histamine pathway

7

-prazole (4 uses)

Peptic ulcer
Gastritis
Eso reflux
ZE

8

-prazole (side effects)

Increased risk of C diff and pneumonia
Hip fx
Lowers serum Mg2+ w/ long term use

9

Bismuth (mechanism)

Binds to ulcer base (physical protection for mucous layer)

10

Bismuth (2 uses)

Ulcer healing
Travelers' diarrhea

11

Sucralfate (mechanism)

Binds to ulcer base (physical protection for mucous layer)

12

Sucralfate (2 uses)

Ulcer healing
Travelers' diarrhea

13

Misoprostol (mechanism)

PGE1 analog -> better gastric mucous barrier, decreases acid production

14

Misoprostol (3 uses)

Prevent NSAID-induced peptic ulcers
Maintain PDA
Induce labor (ripens cervix)

15

Misoprostol (side effects)

Diarrhea
Abortion

16

Aluminum hydroxide (use)

Antacid

17

Aluminum hydroxide (side effects)

Constipation, hypophosphatemia, prox m. weakness, osteodystrophy, seizures, hypokalemia

18

Calcium carbonate (use)

Antacid

19

Calcium carbonate (side effects)

Rebound increase in acid
Reduces effectiveness of other drugs (tetracycline)
Hypokalemia

20

Magnesium hydroxide (2 uses)

Antacid
Osmotic laxative

21

Magnesium hydroxide (side effects)

Diarrhea, cardiac arrest, hyporeflexia, hypotension, hypokalemia

22

Magnesium citrate (use)

Osmotic laxative

23

PEG (use)

Osmotic laxative

24

Lactulose (2 uses)

Osmotic laxative
Hepatic encephalopathy or hyperammonemia in general (ACIDIFIES INTESTINAL CONTENT b/c it gets degraded by bac into acetic acid and lactic acid -> NH3 moves in from blood and gets converted to NH4+ -> body poops it out)

25

Infliximab (mechanism)

Monoclonal Ab to TNF-a

26

Infliximab (5 uses)

Crohn
UC
RA
Ankylosing spondylitis
Psoriasis

27

Infliximab (side effects)

Infection (TB reactivation), fever, hypotension

28

Sulfasalazine (mechanism)

Salfapyridine (antibac) + 5-ASA (anti inflammatory)
Activated by colonic bac

29

Sulfasalazine (2 uses)

UC
Crohn

30

Sulfasalazine (side effects)

Sulfonamide toxicity, reversible oligospermia, malaise, nausea

31

Ondansetron (mechanism)

5-HT3 ANTAgonist, decreases vagal stimulation

32

Ondansetron (use)

Antiemetic in post-op chemo pts

33

Ondansetron (side effects)

Headache, constipation

34

Metoclopramide (mechanism and 2 uses)

D2 ANTAgonist (prokinetic and antiemetic), doesn't influence colon transport time
For gastroparesis (in diabetic or post-surgery), antiemetic

35

Metoclopramide (side effects)

Parkinsonian effects
Interactions w/ digoxin and diabetic agents
Contraindicated w/ small bowel obstruction or Parkinson disease

36

Rifaximin (mechanism and use)

Kills intestinal bacteria
For hepatic encephalopathy

37

Penicillamine (mechanism and use)

Copper chelator
Wilson disease

38

Trientine (use)

Wilson disease

39

Orlistat (mechanism and use)

Inhibits intestinal lipase -> inhibits fat absorption
Weight loss tx for obesity