Drug Side Effects Flashcards Preview

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Flashcards in Drug Side Effects Deck (41):
1

Flushing

niacin, vancomycin (red man syndrome), adenosine, dihydropyridine calcium channel blockers

2

Coronary artery vasospasm

cocaine, amphetamines, triptans, ergotamine

3

Dilated cardiomyopathy

doxorubicin, daunorubicin

4

Torsades de pointes (prolonged QT)

potassium channel blockers (class III), sodium channel blockers (class IA), macrolides, haloperidol, chloroquine, protease inhibitors (ritonavir)

5

Thrombocytopenia

heparin, cimetidine

6

Agranulocytosis

clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
-think of the C's + antithyroid drugs

7

Aplastic anemia

chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

8

Gray baby syndrome

chloramphenicol

9

Hemolysis in G6PD deficiency

isoniazid, sulfonamides, primaquine, aspirin (high-dose), ibuprofen, nitrofurantoin, dapsone, fava beans, naphthalene

10

Thrombosis

oral contraceptives

11

Pulmonary fibrosis

amiodarone, bleomycin, busulfan

12

Cough

ace inhibitors

13

Pseudomembranous colitis

clindamycin, amoxicillin/ampicillin

14

Hepatic necrosis

halothane, acetaminophen, valproic acid, amanita phalloides (mushroom toxin)

15

Hepatitis

isoniazid

16

Tertiary adrenal insufficiency

corticosteroid withdrawal

17

Gynecomastia

"Some drugs cause awesome knockers"
Spirinolactone, Digoxin, Cimetidine, Alcohol, Ketoconazole (and estrogens)

18

Hot flashes

tamoxifen, clomiphene

19

Hypothyroidism

amiodarone, lithium, sulfonamides

20

Gout

diuretics (loop and thiazide), niacin, cyclosporine, pyrazinamide

21

Gingival hyperplasia

phenytoin, verapamil

22

Osteoporosis

corticosteroids, heparin

23

Photosensitivity

Tetracycline, amiodarone, sulfonamides

24

Stevens-Johnson syndrome

Steve Jobs made APPLE PCS - Allopurinol, Phenytoin, Phenobarbital, Lamotrigine, Ethosuxamide, Penicillin, Carbamazepine, Sulfonamide

25

Drug-induced lupus

sulfonamides, hydralazine, isoniazid, procainamide, phenytoin (SHIPP)

26

Tendinitis/cartilage damage

fluoroquinolones

27

Interstitial nephritis

NSAIDs, furosemide, antibiotics

28

Diabetes insipidus

lithium, demeclocycline

29

Fanconi syndrome

expired tetracycline

30

Hemorrhagic cystitis

cyclophosphamide, ifosfamide

31

Parkinson-like syndrome

metaclopramide, antipsychotics, reserpine

32

Cinchonism (dizziness, HA, vision change, tinnitus)

quinidine, quinine

33

Seizures

bupropion, imipenem/cilastatin, isoniazid, tramadol, metoclopramide, benzos/alcohol withdrawal

34

Tardive dyskinesia

antipsychotics, metoclopramide

35

Disulfiram-like rxn

metronidazole, certain cephalosporins, procarbazine, first-generation sulfonylureas, disulfiram

36

Nephrotoxicity + Neurotoxicity

aminoglycosides, cisplatin, polymixins

37

Nephrotoxicity + Ototoxicity

aminoglycosides (streptomycin), vanco, loop diuretics, cisplatin

38

Anticholinergic effects

atropine, TCAs, H-1 blockers, low-potency neuroleptics

39

Induce Cyp450 enzymes

Coronas, Guiness, and PBRS induce chronic alcoholism - Carbamazepine, Griseofulvin, Phenytoin, Rifampin, St. Johns wort, Chronic alcohol use

40

SE of Phenytoin

"Phenytoin Has Given MD'S Frustation" - Peripheral neuropathy, Hirsuitism, Gingival hyperplasia, Megaloblastic anemia, Drug-induced lupus, SJS, Fetal hydantoin syndrome

41

Drugs that can be harmful in sulfa allergy

"Sulfa Pills Frequently Cause Terrible Allergy Symptoms" - Sulfasalazine, Probenicid, Furosemide, Celecoxib, Thiazides/TMP-SMX, Acetazolamide, Sulfonylureas