Drug Side Effects

Question 1

Flushing

Answer 1

niacin, vancomycin (red man syndrome), adenosine, dihydropyridine calcium channel blockers

Question 2

Coronary artery vasospasm

Answer 2

cocaine, amphetamines, triptans, ergotamine

Question 3

Dilated cardiomyopathy

Answer 3

doxorubicin, daunorubicin

Question 4

Torsades de pointes (prolonged QT)

Answer 4

potassium channel blockers (class III), sodium channel blockers (class IA), macrolides, haloperidol, chloroquine, protease inhibitors (ritonavir)

Question 5

Thrombocytopenia

Answer 5

heparin, cimetidine

Question 6

Agranulocytosis

Answer 6

clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
-think of the C’s + antithyroid drugs

Question 7

Aplastic anemia

Answer 7

chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

Question 8

Gray baby syndrome

Answer 8

chloramphenicol

Question 9

Hemolysis in G6PD deficiency

Answer 9

isoniazid, sulfonamides, primaquine, aspirin (high-dose), ibuprofen, nitrofurantoin, dapsone, fava beans, naphthalene

Question 10

Thrombosis

Answer 10

oral contraceptives

Question 11

Pulmonary fibrosis

Answer 11

amiodarone, bleomycin, busulfan

Question 12

Cough

Answer 12

ace inhibitors

Question 13

Pseudomembranous colitis

Answer 13

clindamycin, amoxicillin/ampicillin

Question 14

Hepatic necrosis

Answer 14

halothane, acetaminophen, valproic acid, amanita phalloides (mushroom toxin)

Question 15

Hepatitis

Answer 15

isoniazid

Question 16

Tertiary adrenal insufficiency

Answer 16

corticosteroid withdrawal

Question 17

Gynecomastia

Answer 17

“Some drugs cause awesome knockers”

Spirinolactone, Digoxin, Cimetidine, Alcohol, Ketoconazole (and estrogens)

Question 18

Hot flashes

Answer 18

tamoxifen, clomiphene

Question 19

Hypothyroidism

Answer 19

amiodarone, lithium, sulfonamides

Question 20

Gout

Answer 20

diuretics (loop and thiazide), niacin, cyclosporine, pyrazinamide

Question 21

Gingival hyperplasia

Answer 21

phenytoin, verapamil

Question 22

Osteoporosis

Answer 22

corticosteroids, heparin

Question 23

Photosensitivity

Answer 23

Tetracycline, amiodarone, sulfonamides

Question 24

Stevens-Johnson syndrome

Answer 24

Steve Jobs made APPLE PCS - Allopurinol, Phenytoin, Phenobarbital, Lamotrigine, Ethosuxamide, Penicillin, Carbamazepine, Sulfonamide

Question 25

Drug-induced lupus

Answer 25

sulfonamides, hydralazine, isoniazid, procainamide, phenytoin (SHIPP)

Question 26

Tendinitis/cartilage damage

Answer 26

fluoroquinolones

Question 27

Interstitial nephritis

Answer 27

NSAIDs, furosemide, antibiotics

Question 28

Diabetes insipidus

Answer 28

lithium, demeclocycline

Question 29

Fanconi syndrome

Answer 29

expired tetracycline

Question 30

Hemorrhagic cystitis

Answer 30

cyclophosphamide, ifosfamide

Question 31

Parkinson-like syndrome

Answer 31

metaclopramide, antipsychotics, reserpine

Question 32

Cinchonism (dizziness, HA, vision change, tinnitus)

Answer 32

quinidine, quinine

Question 33

Seizures

Answer 33

bupropion, imipenem/cilastatin, isoniazid, tramadol, metoclopramide, benzos/alcohol withdrawal

Question 34

Tardive dyskinesia

Answer 34

antipsychotics, metoclopramide

Question 35

Disulfiram-like rxn

Answer 35

metronidazole, certain cephalosporins, procarbazine, first-generation sulfonylureas, disulfiram

Question 36

Nephrotoxicity + Neurotoxicity

Answer 36

aminoglycosides, cisplatin, polymixins

Question 37

Nephrotoxicity + Ototoxicity

Answer 37

aminoglycosides (streptomycin), vanco, loop diuretics, cisplatin

Question 38

Anticholinergic effects

Answer 38

atropine, TCAs, H-1 blockers, low-potency neuroleptics

Question 39

Induce Cyp450 enzymes

Answer 39

Coronas, Guiness, and PBRS induce chronic alcoholism - Carbamazepine, Griseofulvin, Phenytoin, Rifampin, St. Johns wort, Chronic alcohol use

Question 40

SE of Phenytoin

Answer 40

"Phenytoin Has Given MD'S Frustation" - Peripheral neuropathy, Hirsuitism, Gingival hyperplasia, Megaloblastic anemia, Drug-induced lupus, SJS, Fetal hydantoin syndrome

Question 41

Drugs that can be harmful in sulfa allergy

Answer 41

"Sulfa Pills Frequently Cause Terrible Allergy Symptoms" - Sulfasalazine, Probenicid, Furosemide, Celecoxib, Thiazides/TMP-SMX, Acetazolamide, Sulfonylureas