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Drug toxicities Flashcards

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1
Q

drugs that cause coronary vasospam

A
  1. Cocaine
  2. sumatriptan
  3. ergot alkaloids (Bromocriptine)
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2
Q

drugs that cause cutaneous flushing

A
  1. VANCOMYCIN
  2. Adenosine
  3. Niacin
  4. Ca2+ channel blockers
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3
Q

drugs that cause Dilated cardiomyopathy

A

Anthracyclines (eg. doxorubicin, daunorubicin)

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4
Q

how to prevent antracyclines mediated dilated cardioyopathy

A

dexrazoxane

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5
Q

drugs that cause Torsade de pointes

A

ABCDE

  1. AntiArrhythmics (class IA, III)
  2. AntiBiotics (eg. Macrolides)
  3. AntiCychotices (eg. haloperidol)
  4. AntiDepressants (eg. TCA)
  5. AntiEmetics (ondansetron
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6
Q

torsade de pointes - treatment

A

Magnesium sulfate

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7
Q

other causes of torsade de pointes beside drugs

A

hypokalemia

hypomagnisemia

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8
Q

drugs that cause HPA adrenocortical insufficinecy

A

HPA suppression 2ry to glucocorticoid withdrawal

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9
Q

drugs that cause Hot flashes

A
  1. Clomiphene

2. Tamoxifen

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10
Q

drugs that cause hyperglycemia

A
  1. Tacrolimus
  2. protease inhibitors
  3. Niacin
  4. hydrochlorothiazide
  5. Corticosteroids
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11
Q

drugs that cause hypothyroidism

A
  1. Lithium
  2. amiodarone
  3. sulfonamides
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12
Q

drugs that cause acute cholestiatic hepatitis and jundice

A

Erytrhomycin (Macrolides)

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13
Q

drugs that cause Diarrhea

A
  1. Acamprosate -
  2. Acarbose
  3. cholinesterase inhibitors
  4. colchicine
  5. erythromycin -
  6. ezetimibe
  7. metformin
  8. misoprostol -
  9. orlistat
  10. pramlintide -
  11. quinidine -
  12. SSRIs
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14
Q

drugs that cause Focal to massive hepatic necrosis

A
  1. Halothane
  2. Amanita phalloides (death cap mushroom)
  3. Valproic acid
  4. Acetaminophen
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15
Q

drugs that cause hepatitis

A
  1. Rifampin
  2. Isoniazid
  3. Pyrazinamide
  4. Statins
  5. fibrates
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16
Q

drugs that cause Pancreatitis

A

Drugs Causing A Violent Abdominal Distress

  1. Didanosine
  2. Corticosteroids
  3. Alchohol
  4. Valproic acid
  5. Azathioprine
  6. Diuretics (furosemide, thiazides)
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17
Q

drugs that cause Pill-induced esophagitis

A
  1. Tetracyclines
  2. biphosphanates
  3. Potasium chloride
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18
Q

Pill-induced esophagitis - caustic effects minimized with

A

upright posture and adequate water ingestion

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19
Q

drugs that cause pseudomembranous colitis

A
  1. Clindamycin
  2. ampicillin
  3. cephalosporne
  4. PPIs
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20
Q

Drugs that cause dry cough

A

ACE inhibitors

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21
Q

drugs that cause Pulmonary fibrosis

A
  1. Methotrexate
  2. Bleomycin
  3. Busulfan
  4. Amiodarone
  5. Carmustine
  6. Nitrofurantoin
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22
Q

drugs that cause thrombotic complications

A

OCP

Horomne replacement therapy

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23
Q

drugs that cause thrombocytopenia

A
  1. Heparin
  2. Antiarrhythmics class IA
  3. sulfa
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24
Q

drugs that cause Megaloblastic anemia

Study These Flashcards
A
  1. Phenytoin
  2. Methotrexate
  3. Sulfa drugs
25
drugs that cause Hemolysis in G6PD deficinecy
1. Isonizid 2. Sulfonamies 3. Dapsone 4. Primaquine 5. Aspirin 6. Ibuprofen 7. Nitrofurantoin
26
drugs that cause Gray baby syndrome
Chloramphenicol
27
Direct Coombs-positive hemolytic anemia
1. Methyldopa | 2. penicillin
28
drugs that cause aplastic hemolytic anemia
1. Carbamazepine 2. Methimazole 3. NSAID 4. Benzene 5. Chloramphenicol 6. Propylthiouracil
29
drugs that cause agranulocytosis
1. Clozapine 2. Carbamazepine 3. Propylthuouracil 4. Methimaazol 5. Colchicine 6. Ganciclovir
30
drugs that cause fat redistribution
1. Protease inhibitor | 2. Glucocorticoids
31
drugs that cause gingival hypeplasia
1. Phenytoin 2. Ca2+ channel blockers 3. Cyclosporine
32
drugs that cause gout
1. Pyrazinamide 2. Thiazides 3. Furosemide 4. Niacin 5. Cyclosporine
33
drugs that cause myopathy
1. fibrates 2. niacin 3. colchicine 4. Hydrxychloroquine 5. interferon α 6. penicillamine 7. statins 8. glucocorticoids
34
drugs that causeOsteoprosis
1. corticosteroids | 2. heparin
35
drugs that cause teeth discoloration
Tetracyclines
36
drugs that cause Tendonitis, tendon rupture, and cartilage damage
Fluoroquinolones
37
drugs that cause SLE-like syndrome
1. Sulfa drugs 2. Hydralazine 3. Isoniazid 4. Procainamide 5. Phenytoin 6. Etanercept
38
drugs that cause Stevens Johnson syndrome
1. Anti-epileptic drugs (esp lamotrigine) 2. Allopurinol 3. sulfa drugs 4. penicillin
39
drugs that cause Photosensitivity
1. Sulfonamifes 2. amiodarone 3. Tetracuclines 4. 5-FU
40
drugs that cause Cinchonism
1. Quinidine | 2. Quinine
41
drugs that cause Parkinson like-syndrome
1. Antipsychotics 2. Reserpine 3. Metoclopramide
42
drugs that cause Tarditve dyskinesia
1. Antipsychotics | 2. metoclopramide
43
drugs that cause Seizures
1. isoniazid (vit B6 deficinecy) 2. Bupropion 3. Impipenem/cilastatin 4. Tramadol 5. Enflurane
44
drugs that cause antimuscarinic
1. atropine 2. TCA 3. HI-blockers 4. Antipsychotics
45
drugs that cause disulfiram like reaction
1. Metronidazole 2. certain cephalosporins 3. griseofulvin 4. procarbazine 5. 1st generation sulfonylureas
46
drugs that cause Nephrotoxicity/ototoxicity
1. aminoglycosides 2. vancomycin 3. loop diuretics 4. cisplatin
47
cisplatin toxicity may respond to
amifostine
48
Cytochrome P-450 inducers
1. Chronic alcohol use 2. St John's wort 3. Pheyntoin 4. Phenobarbital 5. Nevirapine 6. Rifampin 7. Griseofulvin 8. Carbamazepine
49
Cytochrome P-450 substrates
1. Anti-epileptics 2. Theophilline 3. Warfarin 4. OCPs
50
Cytochrome P-450 inhibitors
1. Acute alcohol abuse 2. Ritonavir 3. Amiodarone 4. Cimetidine 5. Ciprofloxacin 6. Ketoconazole 7. Suldonamides 8. Isonizid 9. Grapefruit juice 10. Macrolides (except azithromycin)
51
Sulfa drugs - drugs?
1. Sulfonamide antibiotics 2. Sulfasalazine 3. Probenecid 4. Furosemide 5. Acetazolamide 6. Celecoxib 7. Thiazides 8. Suldonylureas
52
Patients with sulfa allergies may develop
1. fever 2. UTI 3. Steven Johnson syndrome 4. hemolytic anemia 5. Thrombocytopenia 6. Agranulocytosis 7. urticaria SYMPTOMS RANGE FROM MILD TO LIFE THREATENING
53
drugs that cause SIADH
1. carbamazepine 2. Cyclophosphamide 3. SSRIs
54
drugs that cause diabetes insibidus
1. Lithium | 2. Demeclocycline
55
drugs that cause Fanconi syndrome
1. Tendofovir 2. Ifosfamide 3. cisplatin 4. expired tetracycline 5. Lead poisoning
56
drugs that cause interstitial nephritis
1. Methicillin 2. NSAID 3. Furosemide
57
drugs that cause Hemorrhagic cystitis
1. Cyclophosphamide | 2. Ifosphamide
58
drug induced Hemorrhagic cystitis is prevented by
coadministration of mesna

Pharmacology (9 decks)

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