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Flashcards in Drugs 3 Deck (16)
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1
Q

What are the anthracyclines?

A

daunorubicin, doxorubicin, epirubicin, idarubicin

2
Q

What are the camptothecins?

A

Topoisomerase inhibitors

3
Q

What is Folfirinox?

A

FOLFOX + irinotecan

4
Q

Oxalaplatin SE profile

A

sensory neuropathy, myelosuppression, elevated liver enzymes, emesis, diarrhea

5
Q

BEAM regimen

A

carmustine (BCNU), etoposide, aracytin and melphalan

6
Q

Neulasta SE profile

A

Splenomegaly, splenic rupture, bone pain, extremity pain, ARDS (has been described).

7
Q

General risk of cardiomyopathy with HER2 inhibitors

A

Most of the incidence was in trials in which HER2 inhibitors were combined with anthracyclines, so risk of cardiomyopathy with HER2 inhibitors is actually fairly low

8
Q

Platinum doublet

A
  • Typically refers to cornerstone of treatment for advanced NSCLC
  • platinum compound (cisplatin or carboplatin) + one third generation agent (mainly vinorelbine, gemcitabine or taxanes),
9
Q

KRAS and cetuximab

A

Cetuximab is approved for KRAS wildtype tumors

10
Q

Reported late SE’s of chemoRT for rectal cancer

A

increased frequency and urgency of defecation, chronic perianal dermatitis, dyspareunia, impotence

11
Q

Palbociclib trade name

A

Ibrance

12
Q

Durvalumab trade name

A

Imfinzi

13
Q

Atezolizumab trade name

A

Tecentriq

14
Q

What is the mechanism of action of fluoropyrimidines?

A

Antimetabolites

15
Q

What are the fluoropyrimidines?

A

capecitabine, floxuridine, and fluorouracil (5-FU)

16
Q

Tremelimumab mechanism

A

CTLA-4

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