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Hematology, oncology > Terminology > Flashcards

Terminology Flashcards

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1
Q

“Definitive”

A

Treatment with plan for a cure

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2
Q

Terminology for someone discontinuing treatment

A

“coming off of treatment”

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3
Q

Term for real progression

A

“true progression”

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4
Q

Term for drug approved regardless of PD-L1 level

A

PD-L1 agnostic

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5
Q

What does “y” in pathologic staging denote

A

Treated neoadjuvantly

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6
Q

Poor response to treatment term

A

minimal treatment effect

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7
Q

time until treatment is started

A

time to treatment

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8
Q

patient hasn’t been started on treatment

A

“treatment naive”

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9
Q

TTFT is

A

Time to first treatment

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10
Q

Small number of cells with microdeletion on FISH referred to as…

A

Small clone

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11
Q

Terminology to describe indolent disease

A

“favorable biology”

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12
Q

Progression on chemotherapy referred to as

A

primary progression

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13
Q

Fixed duration therapy

A

Time limited therapy

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14
Q

“line agnostic”

A

Can you use in any lines

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15
Q

giving someone the same drug

A

Retreat

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16
Q

Term for concerning lymph node

A

Pathologic appearing

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17
Q

Treatment break

A

Chemo holiday

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18
Q

Trial that was funded by pharmaceutical company

A

“industry sponsored”

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19
Q

DSS

A

disease specific survival

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20
Q

late relapse

A

distant relapse

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21
Q

Local recurrence term

A

loco-regional recurrence

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22
Q

LVSI

A

lymphovascular space invasion

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23
Q

What is “clinical benefit rate” usually defined as?

A

Response + stable disease

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24
Q

Desperation oncology

A

self explanatory

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25
2 primaries diagnosed at same time (developing at same time) are typically referred to as
Synchronous primaries
26
If it's not de novo metastatic then it's
Metachronous metastatic
27
Rate of disease progression referred to as
Disease tempo
28
Term for radiation therapy target
Target Volume
29
Asthenia meaning
weakness
30
Fanconi anemia inheritance
Autosomal recessive (mostly) can be x-linked
31
Fanconi anemia physical exam findings
thumb hypoplasia + short stature + a few others
32
Fanconi anemia hallmark pathophys
Chromosomal instability/fragility (leading to cell death of hepatopoietic stem cells and progressive bone marrow failure)
33
Fanconi anemia lab features
macrocytic anemia Pancytopenia Bone marrow failure by age 40 *increased risk of solid tumors
34
Fanconi anemia treatment
Transplant *careful planned conditioning regimen given chromosomal instability
35
Dyskeratosis congenita hallmark pathophys
Telomere biology disorder
36
Dyskeratosis congenita classic features
- abnormal skin pigmentation - nail dystrophy - leukoplakia
37
Dyskeratosis congenita other clinical features
- pulmonary fibrosis - cirrhosis - malignancies - bone marrow failure by age 30
38
Dyskeratosis congenita testing
telomere length testing --
39
Dyskeratosis congenita treatment
anabolic steroids (short term) HSCT
40
Schwachman-Diamond syndrome inheritance
autosomal recessive
41
Schwachman-Diamond syndrome clinical features
- pancreatic insufficiency - BM dysfunction - neutropenia - MDS/AML in young adults, usually males
42
Schwachman-Diamond mutation
SBDS
43
Schwachman-Diamond syndrome treatment
G-CSF (assuming no myeloid malignancy) Allo SCT for BM issues
44
Diamond blackfan anemia inheritance
autosomal dominant
45
Diamond blackfan anemia clinical features
- infant with red cell aplasia - increased cancer risk
46
Diamond blackfan anemia treatment
- steroids - transfusions - HSCT
47
Congenital dyserythropoetic anemia pathophys
ineffective erythropoeisis leading to anemia
48
Congenital dyserythropoetic anemia inheritance
autosomal recessive
49
Congenital dyserythropoetic anemia I clinical features
- childhood - hemolytic anemia - binucleated erythroblasts
50
Cyclic neutropenia treatment
G-CSF
51
Severe congenital neutropenia clinical features
- severe ANC in childhood + fevers and severe infections
52
Severe congenital neutropenia gene association
ELANE mutation
53
Thrombocytopenia with absent radi (TAR) clinical features
- hypomegakaryoctyic thrombocytopenia + bilateral radial aplasia (but normal thumb) - hemorrhagic manifestations at birth - transient (improves after infancy)
54
WHIM syndrome stands for
warts hypogammaglobulinemia infections myelokathexis
55
WHIM syndrome inheritance
autosomal dominant
56
GATA2 deficiency inheritance
autosomal dominant
57
GATA2 deficiency clinical features
very high risk of MDS
58
How is cure typically defined?
5 year recurrence free survival
59
Oncotype and other molecular profiling tools referred to as
Genomic classifiers
60
Walsh quote for what to do with the absence of data
Absence of evidence is not the same thing as evidence of absence
61
Basic term for resistant disease
Subclone
62
"Basic science rationale for a clinical trial"
Preclinical rationale
63
Term for tumor arising within a pulmonary bronchus
endobronchial
64
Term for describing molecular profile of a tumor
Mutational status
65
Remission
Synonymous with partial or complete response
66
Median time to response in solid tumors
6-8 weeks
67
PET response terminology
partial or complete metabolic response
68
Term for chemotherapy that increases risk for hematologic malignancy
Leukemogenic
69
Using a drug that is not currently approved is referred to as
Off-label use
70
Term to use for something that is positive on PET
PET avid
71
What does myeloablative chemotherapy refer to?
High dose chemotherapy, ie conditioning regimens before transplant to wipe out marrow
72
Using imaging to alter treatment midway through
Response adapted therapy

Hematology, oncology (218 decks)

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