Flashcards in Drugs Deck (15)
Substrates: Cyclosporine mechanism: genetically less important than other drug metabolism genes b/c activity continuous and unimodal
Ketoconazole, grapefruit juice inhibit....
Substrates: Tricyclic antidepressants and codeine (activates codeine->morphine)
Quinidine, Fluoxetine, Paroxetine inhibit...
20% of caucasians need lower dose of ..... because they are poor metabolizers
Modifies risk of cancers though differences in acetylation of carcinogens, Important in Phase II pathway
Isoniazid for TB mechanism
Acts on NAT
5% of kids with ALL (leukemia) poor metabolizers (absent activity)--> will KILL child (immunosuppression) if don't test for it (functional assay)
Acts on TMPT
X-linked enzyme -Deficient individuals susceptible to hemolytic anemia after sulfa or dapsone drug exposures
Sulfonamide antibiotics, dapsone are substrates for...
VKORC1 reduces vitamin K so that vitamin K can be recycled and used to make more coagulation factors