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Name some Anti-platelet drugs and there adverse side effects

Aspirin (Plavix)

Adverse S/E: risk for serious bleeding episodes; GI complaints,tinnitus, thrombocytopenia


Name 3 major Anticoagulants, there therapeutic levels(if any), common uses, and adverse effects

1) Heparin
-aPTT is 1.5-2.5 the normal control level
-Sub-Q or IV for venous thrombosis, pulmonary embolism, thromboembolic complications
-Serious bleeding episodes; severe hypotension, injection site reaction, thrombocytopenia

2) Lovenox
-Monitor aPPT
-Sub-Q for DVT, pulmonary embolism, and after certain types of surgeries like a hip replacement
-serious bleeding episodes

3) Warfarin Sodium (Coumadin)
-therapeutic INR is 2.0-3.0 and PT is 1.5-2.5 xcontrol
-antidote is Vitamin K
-mostly orally or IV for DVT, pulmonary embolism, TIA, prophylactic for cardiac valves
-serious bleeding episodes; hypersensitivity reactions, bronchospasms, anaphylaxis


Name some Thrombolytics : the way it works, adverse side effects, and any need to knows

(TNKase) (Retevase) (tPA) , Streptokinase, Urokinase

-they dissolve clots and are used for an acute MI, pulmonary embolism, or acute ischemic stroke

-administered IV generally within 4 hours

-adverse s/e are serious risk for bleeding, bronchospasms, hemorrhage, and anemia

-Antidote is Amicar


What are some Plasminogen Inactivators, uses, and adverse effects

(Amicar) used for promoting clots to treat excessive bleeding

- adverse effects thrombophlebitis, HA, and orthostatic hypotension


Name some Hemopoietic Agents, common uses, and adverse effects

Ferrous Sulfate (Ferosol,Slow FE) ; Ferrous Fumarate (Femiron) ; Ferrous Gluconate (Fergon)

-that treats iron deficiency anemia

-taken orally, at bedtime
-avoid taking with dairy products, antacids, or tetracyclines

-adverse side effects include GI complaints, seizures, and anaphylaxis


Name the common use for Iron Dextran, the route, adverse effects, and and need to know information

(Dexferrum, Imfed)

-given when oral iron is not an option for tx of iron deficiency anemia

-IV or IM (test dose always given first before administering remaining dosage) IM given w/z-track technique

*contradicted in patients with acute renal disease or active infections

- serious adverse effects include: anaphylaxis, coma, fatal cardiac arrhythmias, & circulatory collapse


Vitamin B-12 Cyancobalamin
Common uses, route, and side effects

(Anacobin, Nascobal)

-tx of megablastic anemias including pernicious anemia

-IM, Sub Q, or nasal routes

-adverse effects are fever, diarrhea, pruritis, flushing,
-serious adverse effects are cardiac failure, thrombosis, pulmonary edema


Folic Acid, Vitamin B9


-tx of folic acid deficiency
-given orally, IV, IM, or Sub-Q

-adverse effects are bronchospasms, rash, pruritis, general malaise, anaphylaxis
-may cause urine to turn darker yellow


Erythropoietin Stimulating Agents

(Epoetin Alfa) (Darbepoetin Alfa)

-for anemias with chronic renal failure, HIV infection, chemotherapy, to decrease the need for blood transfusions in surgical patients

-IV or SubQ, hemoglobin should never exceed 12g/dl

-adverse effects are HTN, bone pain, muscle aches, HA, fever
*Monitor BP
*only one dose per vial and do NOT shake the solution