drugs

Question 1

pseudoephedirine, phenylephrine mechanism of action

Answer 1

α-adrenergic agonists

Question 2

pseudoephedirine, phenylephrine: use

Answer 2

A. to reduce 1. hyperemia 2. edema 3. nasal congestion
B. open obstructed eustachian tubes
C. pseudoephedrine ilicity used to make methamphetamine

Question 3

pseudoephedirine, phenylephrine - toxicity

Answer 3

1. hypertension

2. CNS stimulation/anxiety (pseudoephedrine)

Question 4

pseudoephedrine ilicity used to make

Answer 4

methamphetamine

Question 5

α-adrenergic agonists used as nasal decongestants

Answer 5

1. pseudoephedirine

2. phenylephrine

Question 6

dextromethorphan - use

Answer 6

antitussive

Question 7

dextromethorphan - mechanism of action

Answer 7

antagonizes NMDA glutamine receptrors

Question 8

dextromethorphan - structure

Answer 8

synthetic codeine analog

Question 9

dextromethorphan - antidote for overdose

Answer 9

naloxone

Question 10

dextromethorphan - side effects

Answer 10

1. mild opioid effect (when used in excess)
2. mild abuse potential
3. serotonin syndrome (if combined with with other seretonergic agents)

Question 11

dextromethorphan combined with seretonergic agents

Answer 11

seretonin syndrome

Question 12

dextromethorphan antagonizes

Answer 12

NMDA glutamine receptros

Question 13

expectorants drugs

Answer 13

1. Guaifenesin

2. N-acetylcysteine

Question 14

Guaifenesin - mechanisms of action

Answer 14

thins respiratory secreations (BUT DOES NOT SUPPRESS COUGH REFLEX)

Question 15

Guaifenesin - cough reflex

Answer 15

Guaifenesin does not suppress cough reflex

Question 16

N-acetylcysteine - mechanism of action

Answer 16

mucolytic

can loosen mucous plugs in COPD and CF patients by disrupting disulfide bonds

Question 17

N-acetylcysteine can loosen mucus plugs by

Answer 17

disrupting disulfide bonds

Question 18

N-acetylcysteine - used for

Answer 18

1. cystic fibrosis
2. COPD
3. antidote for acetaminophen overdose

Question 19

H1 blockers - mechanism of action

Answer 19

REVERSIBLE inhibitors of H1 histamine receptors

Question 20

H1 blockers - reversible or irreversible

Answer 20

REVERSIBLE

Question 21

H1 blockers are divided to

Answer 21

1st generation

2nd generation

Question 22

1st generation H1 blockers - drugs

Answer 22

1. diphenhydramine
2. dimenhydrinate
3. chlorpheniramine

Question 23

2nd generation H1 blockers - drugs

Answer 23

• ADINE + cetirizine
  1. loratadine
  2. fexofenadine
  3. desloratadine
  4. cetirizine

Question 24

1st generation H1 blockers - used for

Answer 24

1. allergy
2. motion
3. sleep aid

Question 25

2nd generation H1 blockers - used for

Answer 25

allergy

Question 26

1st generation H1 blockers - toxicity

Answer 26

1. sedation 2. antimuscarinic 3. anti-a-adrenergic

Question 27

2nd generation H1 blockers - toxicity

Answer 27

sedation (much less than 1st generation)

Question 28

1st vs 2nd generation according sedation (why)

Answer 28

2nd generation is FAR LESS sedating than 1st generation because of decreased entry into CNS

Question 29

pulmonary hypertension drugs - categories

Answer 29

1. endothelin receptor antagonists 2. PDE-5 inhibitors 3. Prostacyclin analogs

Question 30

pulmonary hypertension drugs - categories and drugs

Answer 30

1. endothelin receptor antagonists --> BOSENTAN 2. PDE-5 inhibitors --> SILDENAFIL 3. Prostacyclin analogs --> EPOPROSTENOL, ILOPROST

Question 31

bosentan toxicity

Answer 31

hepatotoxicity

Question 32

pulmonary hypertension drugs - PDE-5 inhibitors - drugs

Answer 32

sildenafil

Question 33

pulmonary hypertension drugs - PDE-5 inhibitors - mechanism of action

Answer 33

inhibit cGMP PDE5 and prolong vasodilatory effect of nitric oxide

Question 34

pulmonary hypertensrion - prostacyclin analogs side effects

Answer 34

1. flushing | 2. jaw pain

Question 35

pulmonary hypertensrion - prostacyclin analogs - drugs

Answer 35

1. epoprostenol | 2. iloprost

Question 36

pulmonary hypertensrion - prostacyclin analogs - mechanism of action

Answer 36

prostacyclins (PGI2) with direct vasodilatory effects on pulmonary and systemic arterial vascular beds inhibit platelet aggregation

Question 37

pulmonary hypertension treatment - drug with hepatotoxicity

Answer 37

bosentan

Question 38

chlorpheniramine - toxicity

Answer 38

1. sedation 2. antimuscarinic 3. anti-a-adrenergic

Question 39

lotaradine - used for

Answer 39

allergy

Question 40

H1 first generation blockers - used for

Answer 40

allergy motion sickness sleep aid