Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

respiratory > pulmonary hypertension and drugs > Flashcards

pulmonary hypertension and drugs Flashcards

(40 cards)

Start Studying
1
Q

Normal mean pulmonary pressure

A

10-14 mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

pulmonary hypertension: (value)

A

more than 25 mmHg at rest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

pulmonary hypertension results in …. (Histology)

A
  1. arteriosclerosis 2. medial hypertrophy 3. intimal fibrosis
    OF PULMONARY ARTERIES
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pulmonary hypertension - course

A

severe respiratory distress –> cyanosis and RVH –>

death from decompensated cor pulmonale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

classification group of pulmonary hypertension - number

A

5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

classicfication group of pulmonary hypertension - based on

A

cause and treatment options

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PH

A

pulmonary hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which are the classicfication group of pulmonary hypertension

A
  1. pulmonary arterial hypertension (PAH)
  2. PH due to left heart disease
  3. PH due to lung disease or hypoxia
  4. chronic thromboembolic PH
  5. multifactorial PH
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

multifactorial pulmonary hypertensions - causes

A
  1. hematologic disorders
  2. systemic disorders
  3. metabolic disorders
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

chronic thromboembolic pulmonary hypertensions - pathophysiology

A

recurrent microthrombi –> decreased sectional area of pulmonary vascular bed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

pulmonary hypertensions due to lung disease or hypoxia - pathophysiology

A
  1. destruction of lung parenchyma

2. hypoxemic vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

pulmonary hypertensions due to lung disease or hypoxia - destruction of lung parenchyma example

A

COPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

pulmonary hypertensions due to lung disease or hypoxia - hypoxemic vasoconstriction

A
  1. obstructive sleep apnea

2. living in high altitude

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

pulmonary hypertensions due to left heart disease - is often due to

A
  1. systolic dysfunction
  2. diastolic dysfunction
  3. valvular disease such as mitral stenosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

pulmonary arterial hypertension (PAH) - idiopathic - prognosis

A

poor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

pulmonary arterial hypertension (PAH) - causes

A
  1. idiopathic
  2. drugs
  3. connective tissue disease
  4. HIV infection
  5. portal hypertension
  6. congenital heart disease
  7. schistosomiasis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

pulmonary arterial hypertension (PAH) - idiopathic - pathophysiology

Study These Flashcards
A

often due to inactivation mitation in BMPR2 gene

18
Q

BMPR2 gene - normal action

Study These Flashcards
A

inhibits vascular SMCs proliferation

19
Q

pulmonary arterial hypertension (PAH) also includes

Study These Flashcards
A
  1. pulmonary venous occlusive disease

2. persistent PH of newborn

20
Q

pulmonary arterial hypertension (PAH) - drugs that cause it

Study These Flashcards
A
  1. amphetamines

2. cocaine

21
Q

idiopathic pulmonary arterial hypertension (PAH) - special feature

22
Q

pulmonary hypertension drugs - categories

Study These Flashcards
A
  1. endothelin receptor antagonists
  2. PDE-5 inhibitors
  3. Prostacyclin analogs
23
Q

pulmonary hypertension drugs - categories and drugs

Study These Flashcards
A
  1. endothelin receptor antagonists –> BOSENTAN
  2. PDE-5 inhibitors –> SILDENAFIL
  3. Prostacyclin analogs –> EPOPROSTENOL, ILOPROST
24
Q

pulmonary hypertension drugs - endothelin receptor antagonists - drug and toxicity

Study These Flashcards
A

bosentan

hepatotoxicity

25
pulmonary hypertension drugs - endothelin receptor antagonists - monitor
monitor LFTs
26
pulmonary hypertension drugs - endothelin receptor antagonists - drug and mechanism of action
Bosentan: competitively antagonize endothelin-1 receptors --> decreases pulmonary vascular resistance
27
pulmonary hypertension drugs - PDE-5 inhibitors - drugs
sildenafil (viagra)
28
pulmonary hypertension drugs - PDE-5 inhibitors - mechanism of action
inhibit cGMP PDE5 and prolong vasodilatory effect of nitric oxide
29
pulmonary hypertension drugs - PDE-5 inhibitors - they also used for
erectile dysfunction
30
sildenafil - used for
1. pulmonary hypertension | 2. erectile dysfunction
31
prostacyclin analogs side effects
1. flushing | 2. jaw pain
32
prostacyclin analogs for pulmonary hypertension - drugs
1. epoprostenol | 2. iloprost
33
prostacyclin analogs for pulmonary hypertension - mechanism of action
prostacyclins (PGI2) with direct vasodilatory effects on pulmonary and systemic arterial vascular beds inhibit platelet aggregation
34
pulmonary hypertension treatment - categories
1. endothelin receptor antagonists --> BOSENTAN 2. PDE-5 inhibitors --> SILDENAFIL 3. Prostacyclin analogs --> EPOPROSTENOL, ILOPROST
35
pulmonary hypertension treatment - drug with hepatotoxicity
bosentan
36
hiv infection - type of pulmonary hypertension
pulmonary arterial hypertension
37
type of pulmonary hypertension with poor prognosis
pulmonary arterial hypertension
38
obstructive sleep apnea - type of pulmonary hypertension
PH due to lung disease or hypoxia
39
portal hypertension - type of pulmonary hypertension
pulmonary arterial hypertension
40
pulmonary hypertension treatment - categories
1. endothelin receptor antagonists --> BOSENTAN 2. PDE-5 inhibitors --> SILDENAFIL 3. Prostacyclin analogs --> EPOPROSTENOL, ILOPROST

respiratory (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions