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Flashcards in drugs Deck (12):
1

How to distinguish between the two classes of local anesthetics
-esters
-amides

Amides: two i’s

Esters: one or no i’s

2

Side effects of antimuscarinics

Red as a beet: flushing w/ decreased sweating
Dry as a bone: dry skin and mucous membranes
Blind as a bat: mydriasis w/ loss of accommodation
Mad as a hatter: delirium
Hot as a hare: hyperthermia
-constipation and urinary retention

3

Location of where antiemetics work
-what drugs are used

Vagal afferents -> Chemoreceptor trigger zones in area postrema located in the floor of the fourth ventricle

Drugs:
-DA antagonist: metoclopramide
-5-HT3 antagonist: “setrons”

4

Muscarinic agonist SE

DUMBBELSS
-diarrhea
-urination
-miosis (constriction of the pupil)
-bronchospasm
-bradycardia
-excitation of CNS and skeletal ms
-Lacrimation
-Sweating
-Salivation

5

MOA of the only drug available that will help prolong ALS pts life

Riluzole: glutamate release inhibitor, glutamate receptor blocker, and Na channel blocker

6

Pt on antidepressants is brought to ER w/ diaphoresis, severe HA, and tachycardia
-was watching football, drinking a beer and eating pizza when it started
-VS: increased pulse and BP

What class of drugs was he on?

Monoamine oxidase inhibitors =
-was eating tyramine containing foods: cheese and beer
*tyramine will enter synaptic terminals and displace massive amounts of NE from them -> sympathetic crisis

MOA: phenelzine, tranylcypromine, isocarboxazid

7

TCA used to tx OCD

Clomipramine

8

45 y/o female presents w/
-severe upper quadrant abdominal pain and nausea after eating fatty meals
-cholangiogram shows no stones in biliary duct
-increased AST and ALT on labs
-US: hepatomegaly but not abnml in biliary tree

History of tx w/ what anesthetic would cause these SE?

Halothane -> causes hepatitits

9

Binds to IL-2 receptor on activated T-cells

Basiliximab
-kidney transplant rejection prophylaxis

10

Inhibits T cell proliferation by binding to serine-threonine kinase mTOR

Sirolimus
-kidney transplant rejection prophylaxis

11

Inhibits calcineurin mediated transcription of IL-2

Tacrolimus
-kidney, heart, and liver transplant rejection

12

What cases red man syndrome (maculopapular rash) on pts being tx w/ vancomycin

D/t infusion rate being too rapid