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Flashcards in MSK Deck (10):
1

-loss of motor function of the intrinsic hand muscles
-numbness along inner aspect of hand, forearm, and upper arm
-total claw hand
-possible horner syndromer

Most likely d/t injury to

Lower trunk of brachial plexus = Klumpke paralysis

MC causes: grabbing something to stop oneself
-delivering a baby w/ arms in the extended position above the head

2

-loss of motor function to deltoid ms and teres minor (abduction and lateral rotation)
-sensory loss in upper lateral portion of arm

Most likely d/t

Axillary nerve
-fracture fo surgical neck of the humerus
-dislocation of head of the humerus

3

-wrist drop
-loss of motor function to major extensor ms of arm and forearm
-sensory loss on radial dorsal portion of the hand

Most likely d/t injury to

Radial n
-med humeral fractures
-saturday night palsy: falls asleep w/ arm over back of chair

4

MC injury that causes ulnar nerve damage

Trauma to elbow (where is passes through cubital tunnel)

5

Stretching a muscle does what to its passive and active tension

Increases passive tension
Decreases active tension

Depends on overlap between actin and myosin:
-stretching a ms decreases degree of overlap and thus decreases active tension force

6

-numbness and pain on left aspect of forearm and hand
-claw hand
-can raise arm over head
-decreased radial pulse
-tx: incision of anterior scalene ms (watch out for phrenic n)

Dx
Borders
What is being compressed

Thoracic outlet syndrome

Borders: scalene ms, first rib, clavicle

Compressing: subclavian artery and vein; lower trunk of brachial plexus

7

Diseases involved in collagen deficiency

Scurvy
Osteogenesis imperfecta
Ehlers-Danlos syndromes
Menkes Disease

8

10 y/o boy presents with
-hyper-extensible joints
-frequent joint dislocations
-easy bruising
-PE: short for his age, small jaw

Dx
What is abnormal
Mutation

Ehlers Danlos

Type 1 Collagen (skin, bone, tendon, vasculature)

PLOD1: encodes enzyme lysyl hydroxylase

9

X linked recessive dz characterized by
-sparse, depigmented hair
-seizures
-failure to thrive
-neurodegeneration
-pts nml die before 10 years of age

D/t mutation that leads to loss of copper distribution

Dx
Mutation

Menkes disease

ATP7A
- copper is needed for many enzymes to function
-ex. Lysyl oxidase cannot crosslink triple helix collagen molecules

10

Pt presents w/
-dislocated lens in one or both eyes
-defects in aorta: increased risk of aortic rupture
-tall, slender, w/ elongated fingers and toes

Dx
Defect in
Mutation

Marfan syndrome

Defect in elastin

Mutation: fibrillin-1