Drugs

Question 1

4 anti tumor drugs

Answer 1

Cetuximab
Erlotinib
Trastuzumab
Bevacizumab

“Cheating Boys Eat Trash”

Question 2

Cetuximab MOA

Answer 2

Binds EGF-R

Initiates ADCC

Question 3

Cetuximab AE

Answer 3

Infusion site rxn (brochospasm, HoTN)
Interstitial lung dz
Rash

Question 4

Erlotinib MOA

Answer 4

Tyrosine Kinase inhibitor for mutant EGF-R

Question 5

Erlotinib AE

Answer 5

Corneal Damage
Interstitial Lung Dz
Liver Tox
Diarrhea
Rash (Steven Johnson)

Question 6

Trastuzumab MOA

Answer 6

HER-2 -R blocker

Question 7

Trastuzumab AE

Answer 7

Cardiomyopathy

Injection site Rxn

Question 8

Bevacizumab MOA

Answer 8

Inactivates VEGF

Question 9

Bevacizumab AE

Answer 9

Wound rupture
Bleeding
GI perf

Question 10

Calcineurin inhibitor examples

Answer 10

Tacrolimus

Cyclosporine

Question 11

Drugs that decrease T cell activation for immunosuppression

Answer 11

Tacrolimus
Cyclosporine
Belatacept
Muromumab

“They Can’t Break Me”

Question 12

Calcineurin inhib indications

Answer 12

RA

Transplant rejection prophylaxis

Question 13

Calcineurin inhibitor AE

Answer 13

Hyper-K
Nephrotox
HTN

Question 14

Belatacept MOA

Answer 14

“Pretend CTLA”

Question 15

Belatacept indic

Answer 15

Transplant rejection prophylaxis

Question 16

Muromumab indic

Answer 16

T1 DM

Transplant rejection prophylaxis

Question 17

Muromumab AE

Answer 17

cytokine induced syndrome (chill, fevers, dyspnea)

Question 18

Rituximab MOA

Answer 18

CD20 antibody –> killed by ADCC/complement
Thus dec B cell activation

immunosuppressive drug

Question 19

Rituximab Indic

Answer 19

B-cell lymphoma
MS
Systemic autoimmune Complex Dz
-SLE (lupus)
-RA

Question 20

Rituximab AE

Answer 20

Rash
PML
HBV
Pyogenic bact infect

Question 21

Anticytokine drugs (Immunosuppresion)

Answer 21

"Attack the Evil A.I"
Infliximab
Adalimumab
Etanercept
Anakinra
Tocilizumab

Question 22

Which anticytokine drugs dec TNF via antibodies>

Answer 22

Infliximab

Adaliumab

Question 23

Which anticytokine drug dec TNF via TNF-R

Answer 23

Etancercept

Question 24

Indic of TNF dec drugs

Answer 24

RA
Psoriatic arthritis
Crohn’s (inflix & adal only)

Question 25

AE of TNF dec drugs

Answer 25

Inc risk of TB, HepB GI effects CI: HF

Question 26

ANakinra MOA

Answer 26

Dec IL-1

Question 27

ANakinra INdic

Answer 27

RA | Hereditary fever syndrome (FCAS)

Question 28

Anakinra AE

Answer 28

INjection site rxn

Question 29

Tocilizumab MOA

Answer 29

Dec IL-6

Question 30

Tocilizumab Indic

Answer 30

RA

Question 31

Tocilizumab AE

Answer 31

Inc Infections MOnitor LFTs **Hyperlipidemia**

Question 32

Immunosuppressive drug that is an Antiintegrin & blocks VLA-4

Answer 32

Natalizumab

Question 33

Natalizumab Indic

Answer 33

Inflammatory dz: - MS - IBD - RA

Question 34

Natalizumab AE

Answer 34

PML | Monitor LFTs

Question 35

Prednisone Indic

Answer 35

``` Dec organ transplant rejection Type IV-Th1 hypersensitivity Exacerbation of chronic asthma (Type IV-Th2) RA SLE (lupus) Osteoarthritis Gouty arthritis ```

Question 36

Prednisone AE

Answer 36

``` OBesity dyslipidemia Ostoporosis Skin atrophy GI bleed ``` CI: TB, systemic fungal infection

Question 37

Which therapies target IgE response?

Answer 37

Allergen spicific immunotherapy (SIT) | Omalizumab

Question 38

Allergen SIT MOA

Answer 38

Sub q injections of gradually inc antigens until Treg response through IL-10

Question 39

Allergen SIT indic

Answer 39

Allergic rhinitis | Allergic asthma

Question 40

Allergen SIT AE, CI

Answer 40

AE: Anaphylaxis CI: Severe asthma, CVD

Question 41

Omalizumab MOA

Answer 41

Anti-IgE antibody (Fc position)

Question 42

Omalizumab Indic

Answer 42

Prophylaxis/control of moderate --> severe allergic asthma

Question 43

Omalizumab AE

Answer 43

Injection site rxn | Anaphylaxis

Question 44

Which therapies target mast cell degranulation

Answer 44

Mepolizumab Chlorpherniamine Fexofenadine Montelukast

Question 45

Mepolizumab MOA

Answer 45

anti-IL5

Question 46

Mepolizumab INdic

Answer 46

severe asthma in pts w eosinophils

Question 47

Mepolizumab AE

Answer 47

Injection site rxn | Hypersensitivity

Question 48

Chlorpheniramine, Fexofenadine MOA

Answer 48

anti H1R, 1st & second gen, respectively

Question 49

Chlorpheniramine, Fexofenadine INdic

Answer 49

allergic rhinitis

Question 50

Chlorpheniramine, Fexofenadine AE

Answer 50

sedation | mAchR AE in chlorpheniramine

Question 51

Montelukast MOA

Answer 51

LT-R antag

Question 52

Montelukast indic

Answer 52

asthma | allergic rhinitis

Question 53

Montelukast AE

Answer 53

Neuro crap

Question 54

Which drugs have a reversing response?

Answer 54

Albuterol | API

Question 55

Albuterol MOA

Answer 55

B2 ag

Question 56

Albuterol indic

Answer 56

asthma

Question 57

Albuterol AE

Answer 57

``` tremor CNS effects Cardiac stim -Inc HR -palpitations ```

Question 58

EPI MOA

Answer 58

a1, B1, B2 ag