Drugs

Question 1

Alpha methyl transferase

Answer 1

Blocks tyrosine hydroxylase in noradrenaline/ adrenaline synthesis

Question 2

Carbidopa

Answer 2

Blocks DOPA carboxylase in noradrenaline/ adrenaline synthesis

Question 3

Methyldopa

Answer 3

Displaces noradrenaline

Question 4

Serpine

Answer 4

Depletes vesicular stores of catecholamines

Question 5

Guanethidine

Bretylium

Answer 5

Inhibit noradrenaline from sympathetic nerve terminals

Question 6

Amphetamine
Ephedrine
Tyramine

Answer 6

Displace noradrenaline

Long lasting effects that mimic noradrenaline

Question 7

Yohimbine

Answer 7

Alpha 2 adrenoceptor

Question 8

Adrenaline

Answer 8

Alpha and beta agonist

treat cardiac arrest, anaphylaxis, asthma

Question 9

Dobutamine

Answer 9

Beta 1 agonist

Question 10

Salbutamol

Answer 10

Beta 1 agonist

treat asthma

Question 11

Mirabegron

Answer 11

Beta 3 agonist

treat overactive bladder syndrome

Question 12

Phenylephrine

Answer 12

Alpha 1 agonist

treat nasal decongestion

Question 13

Chloridine

Answer 13

Alpha 2 agonist

treat migraine, hypertension

Question 14

Prazosin

Doxasin

Answer 14

Alpha 1 antagonist

Treat hypertension

Question 15

Metoprolol

Atenolol

Answer 15

Beta antagonist

treat hypertension, angina

Question 16

Timolol

Answer 16

Beta antagonist

treat glaucoma

Question 17

Triethylcholine

Answer 17

Competitive inhibitor of cholinergic transmission
Reacts to give acetyltriethylcholine
Displaces noradrenaline but has no effect when released

Question 18

alpha latroxin

Answer 18

Increase release of ACh at pre synaptic junction

Question 19

Sarin

Answer 19

Acetylcholinesterase inhibitor

Leads to death from overstimulation by ACh

Question 20

hexamethonium

Answer 20

Nicotinic receptor antagonist
Non competitively blocks ion channel
Treat high blood pressure but poorly absorbed and unpredictable

Question 21

Pirenzepine

Answer 21

M1 muscarinic antagonist

Question 22

Gallamine

Answer 22

M2 muscarinic antagonist

Question 23

Nicotine

Answer 23

Nicotinic receptor agonist

Question 24

Pilocarpine

Answer 24

Muscarinic Agonist

Question 25

Omeprazole

Answer 25

Proton pump inhibitor

Question 26

Ranitidine

Answer 26

H2 Blocker

Question 27

Gaviscon

Answer 27

Alignate

Question 28

Amoxicillin | Clarithromycin

Answer 28

Treatments for helicobacter pylori | Proton pump inhibitor

Question 29

CREON

Answer 29

pancreatic cystic fibrosis | replaces lost enzymes

Question 30

Aminosalicylates

Answer 30

Treat ulcerative collitis

Question 31

Infliximab, Adalimumab, Golimumab

Answer 31

Biologics used to treat IBD

Question 32

Corticosteroids (GIT)

Answer 32

Used to treat IBD

Question 33

Laxatives

Answer 33

Stimulent, Saline, Emollient, Bulk

Question 34

Loperamide

Answer 34

Anti diarrhoeal

Question 35

NSAIDs

Answer 35

Block Cyclooxygenase

Question 36

Lipocortin

Answer 36

Inhibits phospholipase A2 | Which inhibits leukotrienes = immunosuppressants

Question 37

Mannitol

Answer 37

osmotic diuretic Increases osmolarity Decreases water reuptake

Question 38

Furosemide | Ethacrynic acid

Answer 38

Loop diuretics | Inhibit NaKCC2 transport

Question 39

Thiazides | e.g bendroflumethiazide

Answer 39

Prevent NaCl reabsorption in DCT

Question 40

Spironolactone

Answer 40

Inhibit aldosterone at DCT and collecting duct

Question 41

Amiloride | Triameterene

Answer 41

Blocks Na+ reabsorption at collecting duct

Question 42

Acyclovir

Answer 42

DNA polymerase inhibitor | Treat herpes

Question 43

Lamivudine | Efavirenz

Answer 43

Reverse transcriptase inhibitors | Treat HIV/AIDS

Question 44

Raltegravir

Answer 44

Integrase Inhibition

Question 45

Saquinavir

Answer 45

Protease inhibitors

Question 46

``` Chloroguine Quinine Mefloguine Artemisin Primaquine ```

Answer 46

Anti - malarial drugs

Question 47

Alkylating agents | Platinum agents

Answer 47

Cel cycle non specific drugs | Prevents separation of DNA

Question 48

Methotraxate

Answer 48

Inhibits dihydrofolate reductase

Question 49

Prococaine/ cocaine

Answer 49

Local anaesthetic | Short

Question 50

Lidocaine

Answer 50

Local anaesthetic | Medium

Question 51

Prilocaine

Answer 51

Local anaesthetic | Medium

Question 52

Bupivacaine

Answer 52

Local anaesthetic | Long ~ hours

Question 53

Halothane

Answer 53

General anaesthetic | Potent but liver toxicity

Question 54

Enflurane

Answer 54

General anaesthetic | Less potent but seizures

Question 55

Isoflurane

Answer 55

General anaesthetic | Fast acting but bad odour

Question 56

Sevoflurane

Answer 56

General anaesthetic | Nice odour but renal damage

Question 57

Botulinum

Answer 57

Binds to presynaptic membrane | Cleaves proteins required for ACh exocytosis

Question 58

Vesamicol

Answer 58

Prevents transport of ACh to carrier vesicles

Question 59

Hemicholinum

Answer 59

Prevents transport of choline into presynaptic bulb

Question 60

Pancuronium | Vencuronium

Answer 60

Non Depolarising blockers Antagonists at nAChRs Decrease EPP

Question 61

Suxamethonium

Answer 61

Depolarising blocker Agonist at nAChRs Increase EPP Not broken down by acetylcholinesterase

Question 62

Edrophonium Neostigmine organophosphates

Answer 62

Acetylcholinesterase Inhibitors