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Hematology > Drugs > Flashcards

Drugs Flashcards

1
Q

alkylators: general

A
  • nitrogen mustards
  • platinum analogs
  • triazenes
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2
Q

alkylators: nitrogen mustards

A
  • nitrogen mustard
  • cyclophosphamide
  • ifosfamide
  • chlorambucil
  • melphalan
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3
Q

alkylators: platinum analogs

A
  • cisplatin
  • carboplatin
  • oxaliplatin
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4
Q

alkylators: triazenes

A
  • dacarbazine
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5
Q

antrhacyclines

A
  • doxorubicin

- daunotubucin

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6
Q

antimetabolics

A
  • methotrexate
  • 5-fluorouracil
  • hydroxyurea
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7
Q

antimetabolic analogs

A
  • pyrimidine analogs: cytarabine (ara-c), gemcitabine

- purine analogs: fludarabine

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8
Q

anti-tumor antibiotics

A
  • bleomycin
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9
Q

plant alkaloids: general

A
  • vinca alkaloids
  • taxanes
  • camptothecins
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10
Q

plant alkaloids: vinca alkaloids

A
  • vincristine
  • vinblastine
  • vinorelbine
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11
Q

plant alkaloids: taxanes

A
  • paclitaxel

- docetaxel

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12
Q

plant alkaloids: camptothecins

A
  • irinotecan
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13
Q

hormones

A
  • glucocorticoids: dexamethasone, prednisone

- androgens: danazol

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14
Q

anti-horomones

A
  • anti-androgens (receptor antagonists)
  • anti-estrogens (receptor antagonists)
  • aromatase inhibitors
  • LH-RH agonists
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15
Q

anti-horomones: anti-androgens

A
  • flutamide

- bicalutamide

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16
Q

anti-horomones: anti-estrogens

A
  • tamoxifen

- raloxifene

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17
Q

anti-horomones: aromatase inhibitors

A
  • anastrozole
  • letrozole
  • exemestane
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18
Q

anti-horomones: LH-RH agonists

A
  • leuprolide

- goserelin

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19
Q

monoclonal antibodies

A
  • trastuzumab
  • bevacizumab
  • cetuximab
  • rituximab
  • eculizumab
  • brentuximab vedotin
  • ipilimumab
  • nivolumab
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20
Q

trastuzumab

A

anti-HER2

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21
Q

bevacizumab

A

anti-VEGF

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22
Q

cetuximab

A

anti-EGFR

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23
Q

rituximab

A

anti-CD20

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24
Q

eculizumab

A

anti-compliment C5

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25
Q

brentuximab vedotin

A

anti-CD30 conjugated to microtubule disrupting agent

26
Q

ipilimumab

A

anti-CTLA4

27
Q

nivolumab

A

anti-PD-1

28
Q

small molecule inhibitors

A
  • imatinib
  • erlotinib
  • ibrutinib
29
Q

imatinib

A

BCR-ABL inhibitor

30
Q

erlotinib

A

EGFR inhibitor

31
Q

ibrutinib

A

Bruton’s tyrosine kinase inhibitor

32
Q

imids

A
  • thalidomide

- lenalidomide

33
Q

demethylating agents

A
  • azacytidine

- decitabine

34
Q

proteasome inhibitors

A
  • bortezomib
35
Q

vitamin A analog

A
  • all trans-retinoic acid (ATRA)
36
Q

arsenical

A
  • arsenic trioxide (ATO)
37
Q

anticoagulants

A
  • heparins
  • direct thrombin inhibitors
  • direct factor Xa inhibitors
  • thrombolytics
  • vitamin K antagonists
  • anti-platelet agens
  • GpIIb/IIIa antagonists
38
Q

anticoagulants: heparins

A
  • unfractionated
  • low molecular weight: enoxaparin, dalteparin
  • fondaparinux
39
Q

anticoagulants: direct thrombin inhibitors

A
  • lepirudin
  • argatroban
  • dabigatran (reversal: idarucizumab)
40
Q

anticoagulants: direct factor Xa inhibitors

A
  • rivaroxaban (reversal: andexanet-alpha)
41
Q

anticoagulants: thrombolytics

A
  • recombinant tPA
42
Q

anticoagulants: vit K antagonists

A
  • warfarin
43
Q

anticoagulants: anti-platelet agents

A
  • aspirin
  • clopidogrel
  • prasugrel
  • NSAIDs (ibuprogen)
44
Q

anticoagulants: GpIIb/IIIa antagonists

A
  • abiciximab
45
Q

pro-coagulants

A
  • vitamin K
  • recombinant factor VIIa
  • desmopressin acetate (DDAVP)
46
Q

anti-fibrinolytics

A
  • aminocaproic acid
47
Q

thrombopoietin mimetics

A
  • romiplostim

- eltrombopag

48
Q

anti-emetics

A
  • serotonin antagonists
  • NK-1 antagonists
  • benzodiazepines
  • glucocorticoids
  • dopaminergic antagonists
49
Q

anti-emetics: serotonin antagonists

A
  • ondansetron
50
Q

anti-emetics: NK-1 antagonists

A
  • aprepitant
51
Q

anti-emetics: benzodiazepines

A
  • lorazepam
52
Q

anti-emetics: glucocorticoids

A
  • dexamethasone
53
Q

anti-emetics: dopaminergic antagonists

A
  • prochlorperazine

- metoclopramide

54
Q

growth factors

A
  • ESAs: epoetin alfa, darbepoetin alfa

- G-CSF: filgrastim, pegfilgrastim

55
Q

supportive to growth factors

A
  • leucovorin
  • mesna
  • dexrazoxane
  • atropine
  • protamine sulfate
  • allopurinol
  • rasburicase
  • diphenhydramine
56
Q

blood bank products

A
  • rbcs
  • fresh frozen plasma
  • platelets
  • granulocytes
  • cryoprecipitate
  • anti-D immune globulin
  • prothrombin complex concentrates
  • factor concentrates and recombinant coagulation factors
  • albumin
  • IVIg
57
Q

anti-D immune globulin

A
  • RhoGAM

- WinRHo

58
Q

prothrombin complex concentrates

A
  • activated PCC = 3-factor

- unactivated PCC = 4-factor

59
Q

factor concentrates

A
  • VIII

- IX

60
Q

recombinant coagulation factors

A
  • VIII
  • IX
  • VIIa

Hematology (6 decks)

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