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Hematology > markers and chemo > Flashcards

markers and chemo Flashcards

1
Q

human hsc stem cell markers

A

Lin- Kit+ CD34+

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2
Q

paroxysmal nocturnal hemoglobinuria

A

CD55 and CD59 NOT expressed

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3
Q

myeloid markers

A
  • myeloperoxidase and lysozyme

- CD13, CD 33, Cd117

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4
Q

lymphoid markers

A
  • Tdt
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5
Q

B markers

A
  • CD10, CD19, CD20
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6
Q

T markers

A
  • CD2, CD3, CD4, CD5, CD8
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7
Q

HL Reed Sternberg Cell

A

CD30 and CD15

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8
Q

non classical HL (nodular lymphocyte)

A

CD20

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9
Q

CLL immunophenotype

A

CD19, CD20, CD23, CD5

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10
Q

carcinoma IHC

A

CD, EMA

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11
Q

breast

A

ER, PR

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12
Q

prostate

A

PSA

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13
Q

lymphoma

A

CD45

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14
Q

melanoma

A

S-100

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15
Q

germ cell

A

beta-HCG, AFP

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16
Q

soft tissue, carcinoma

A

vimentin

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17
Q

GPIb

A

VWF receptor

18
Q

GPIa/IIa

A

collagen receptor

19
Q

GPIIb/IIIa

A

fibrinogen

20
Q

APL translocation

A

t(15, 17) (PML-RAR)

21
Q

AML prognosis (good)

A

t(8, 21), inv(16), t(15, 17)

NPM1, CEBPA

22
Q

AML prognosis (bad)

A

11q23 trans, del 5, del 7

FLT3

23
Q

ALL prognosis (good)

A

t(12, 21), hyperploidy

24
Q

ALL prognosis (bad)

A

t(9, 22), t(4, 11), 11q23 trans, hypoploidy

25
Q

CLL prognostics (bad)

A

unmutated, CD38, ZAP20, 17p del, 11q del

26
Q

CML translocation

A

t(19, 22), BCR-ABL1

27
Q

APL treatment

A
  • ATRA and ATO
28
Q

AML treatment

A

cytarabine and anthracycline

29
Q

ALL treatment

A
  • vincristine, glucocorticoid, anthracycline, L-asparaginase, cytarabine, cyclophosphamide, methotrexate
  • TK inhibitor in Ph+
30
Q

NHL indolent treatment

A

rituximab combo

31
Q

NHL aggressive treatment

A
  • R-CHOP

- rituximab, cyclophosphamide, doxirubicin, vincristin, prednisone

32
Q

HL standard treatment

A
  • ABVD

- adriamycin, bleomycin, vinblastine, dacarbazine

33
Q

HL other

A
  • nitrogen mustard, brentuximab, immune checkpoint inhibitor
34
Q

CLL therapy

A
  • oral: fludarabine, chlorambucil
  • rituximab and alemtuzomab
  • ibrutinib
35
Q

multiple myeloma therapy

A
  • melphalan and cyclophosphamide
  • prednisone and detramethasone
  • thalidomide and lenalidomide
  • bortezomib
36
Q

5q MDS therapy

A

lenalidomide

37
Q

CML therapy

A

TKi, IFNalpha

38
Q

PV therapy

A

aspirin, hydroxyurea, IFN alpha JAK2i

39
Q

ET therapy

A

hydroxyurea, aspirin

40
Q

PMF theraoy

A

mephalan, busulfan, hydroxyurea, JAK2i

Hematology (6 decks)

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