Drugs for Alzheimer's Flashcards Preview

Unit 3: Pharm (drugs only) > Drugs for Alzheimer's > Flashcards

Flashcards in Drugs for Alzheimer's Deck (13):
1

Describe the molecular action of donepezil. What kind of Alzheimer's is it used to treat?

Inhibits AChE; treats mild, moderate, and severe Alzheimer's

2

Describe the molecular action of galantamine. What kind of Alzheimer's is it used to treat?

Inhibits AChE; treats mild to moderate Alzheimer's

3

Describe the molecular action of rivastigmine. What kind of Alzheimer's is it used to treat?

Inhibits AChE and BuChE; treats mild to moderate Alzheimer's

4

Describe the molecular action of tacrine. What kind of Alzheimer's is it used to treat?

Inhibits AChE and BuChE; previously used for mild to moderate Alzheimer's, but is now used very rarely

5

Describe the molecular action of memantine. What kind of Alzheimer's is it used to treat?

NMDA receptor antagonist; treats mild, moderate, and severe Alzheimer's

6

Besides treating Alzheimer's, donepezil and rivastigmine could also be used to treat what 3 CNS diseases?

Parkinson's, dementia with Lewy bodies, and vascular dementia

7

Besides treating Alzheimer's, galantamine and memantine could also be used to treat what CNS disease?

Vascular dementia

8

Describe the metabolism and excretion of donepezil.

Metabolized by P450, excreted in urine

9

Describe the metabolism and excretion of galantamine.

Metabolized by P450, excreted in urine

10

Describe the metabolism and excretion of rivastigmine.

Hydrolyzed by cholinesterases, excreted in urine

11

Describe the metabolism and excretion of memantine.

Not metabolized, excreted unchanged in urine

12

Give 2 reasons why tacrine is now rarely used to treat Alzheimer's.

Hepatotoxicity and has to be taken 4x/day

13

Which Alzheimer's drug can be given as a transdermal patch? List 2 advantages of the patch compared to a pill.

Rivastigmine; better compliance and fewer side effects (ex. nausea, vomiting, diarrhea)