Headache Treatments Flashcards Preview

Unit 3: Pharm (drugs only) > Headache Treatments > Flashcards

Flashcards in Headache Treatments Deck (25):
1

Ergots and triptans are what kind of headache treatment (acute or preventive, specificity)?

Acute, specific for migraines and cluster headaches

2

Analgesics, anti-emetics, NSAIDs, corticosteroids, anxiolytics, and opioids are what kind of headache treatment (acute or preventive, specificity)?

Acute, nonspecific

3

Botox is what kind of headache treatment (acute or preventive, specificity)?

Preventive, specific for migraines and chronic (not episodic) tension-type headaches

4

Muscle relaxants like tizanidine are used in what kind of headache treatment (acute or preventive, specificity?)

Preventive, specific for chronic (not episodic) tension-type headaches

5

Oxygen and anesthetics like lidocaine are used in what kind of headache treatment (acute or preventive, specificity)?

Acute, specific for cluster headaches

6

Short-term preventive therapy for cluster headaches is used for less than a month, and involves administration of what two drugs?

Corticosteroids (short burst, oral) + ergots (daily)

7

Anti-hypertensives like verapamil and anti-epileptics like topiramate and divalproex sodium are used in what kind of headache treatment (acute or preventive, specificity)?

Preventive, specific for migraines and cluster headaches

8

A combination of what 3 drugs makes up the acute, moderate migraine treatment marketed as Excedrin?

Aspirin, acetaminophen, and caffeine

9

What is the most common cause of chronic daily headaches?

Chronic use / overuse of medications

10

What class of drugs is commonly prescribed as acute treatment for patients who wake up with a headache?

Opioids

11

How do ergotamine and DHE treat headaches (what receptor, agonists or antagonists, what nerves)?

5HT agonists in the trigeminal pathway

12

List 2 differences between ergotamine and DHE in treating headaches.

DHE is given as a nasal spray, IM, or IV (while ergotamine is given orally), and causes less side effects (ex. nausea, rebound headache, uterine constriction, vasoconstriction)

13

Ergots are used to treat what kinds of headaches, and are contraindicated in what kinds of patients?

Migraines (acute treatment) and cluster headaches (short-term prevention); contraindicated in pregnancy, hypertension, vascular disease, sepsis, hepatic or renal failure

14

DHE is given intravenously for what severe headache state that lasts more than 72 hours?

Status migrainosus

15

How do the triptans treat headaches (what receptor, agonists or antagonists, what nerves)?

5HT agonists in the trigeminal pathway

16

How does the use of triptans compare to the use of ergots for headache treatment?

Triptans also treat migraines and cluster headaches, but can additionally treat accompanying nausea, vomiting, and photo/phonophobia

17

Which triptan can be given as as a subcutaneous injection for immediate therapy? Which ones can be given as nasal sprays?

Sumatriptan; sumatriptan and zolmitriptan

18

Which calcium channel blocker is most commonly used to treat headache? What kinds of headaches is it used for (acute or preventive; specificity)?

Verapamil; for prevention of migraines with prolonged or disabling auras, complicated migraines, and long-term cluster headaches

19

Which anti-epileptic is most commonly used to treat headache? What kinds of headaches is it used for (acute or preventive; specificity)?

Topiramate; for prevention of migraines and long-term cluster headaches

20

Divalproex sodium is the most common formulation of what chemical? What 4 problems is it used to treat?

Valproic acid; used for (1) all seizures including status epilepticus, (2) bipolar disorder, (3) migraine prevention, and (4) cluster headaches long-term prevention

21

What are 4 unusual and important side effects to watch out for when using divalproex sodium?

Hepatotoxicity, pancreatitis, blood dyscrasias, and teratogenicity

22

What are 5 unusual and important side effects to watch out for when using topiramate?

Metabolic acidosis, kidney stones, weight loss, word-finding/cognitive problems, and acute glaucoma (rare)

23

If a patient is being treated with lithium for long-term prevention of their cluster headaches, what 2 other medications should they take care to avoid, and why?

Indomethacin and Na-depleting diuretics, because they will cause an increase in [Li]

24

Name the 2 β-blockers that are FDA approved for migraine prevention.

Propanolol and timolol

25

Lithium is used for what kind of headache treatment (acute or preventive, specificity)?

Long term preventive for cluster headaches