Drugs for Male GU Disorders - Martin

Question 1

glyburide

Answer 1

sulfonylurea

-increase insulin release from beta cells of pancreas

Question 2

metformin

Answer 2

biguanide

-increase insulin sensitivity

Question 3

most common cause of ED

Answer 3

atherosclerosis

Question 4

alterations in sexual response

Answer 4

SSRIs
antipsychotics - phenothiazines
alcohol

Question 5

tx of ED

Answer 5

phosphodiesterase inhibitors

PG E1 analog

Question 6

PG E1 analog

Answer 6

alprostadil

relaxes trabecular smooth m and dilation of cavernosal arteries

• tx for ED
• injected along penis

Question 7

PDE5 inhibitors

Answer 7

tx for ED

increased cGMP - more smooth m relaxation of corpora cavernosa

Question 8

sildenafil

Answer 8

PDE5 inhibitor

viagra

Question 9

tadalafil

Answer 9

PDE5 inhibitor

cialis

Question 10

avanafil

Answer 10

PDE5 inhibitor

Question 11

vardenafil

Answer 11

PED5 inhibitor

levitra

Question 12

CI for PDE5 inhibitors

Answer 12

nitrates use - myocardial ischemia risk**

Question 13

daily use PDE5 inhibitor

Answer 13

tadalafil

duration of action 36 hours

Question 14

30 minute ED drugs

Answer 14

tadalafil

avanafil

Question 15

1 hour ED drugs

Answer 15

sildenafil

vardenafil

Question 16

adverse of alprostadil

Answer 16

penile pain

Question 17

tx male pattern baldness

Answer 17

finasteride

5 alpha reductase inhibitor

Question 18

tx of BPH

Answer 18

5 alpha reductase inhibitors

alpha1-adrenergic antagonist

Question 19

prazosin

Answer 19

short acting alpha1 antagonist

-tx for BPH

Question 20

long acting alpha1 antagonists

Answer 20

terazosin
doxazosin
alfuzosin
tamsulosin

Question 21

finasteride

Answer 21

5a reducatase inhibitor

Question 22

dutasteride

Answer 22

5a reductase inhibitor

Question 23

smooth m in prostate

Answer 23

alpha1A receptor primarily

Question 24

adverse prazosin

Answer 24

orthostatic HTN and palpitations

Question 25

abnomal ejaculation

Answer 25

with alfuzosin

Question 26

saw palmetto

Answer 26

tx of BPH inhibit 5a reductase and inhibit DHT binding to androgen receptors

Question 27

tx urinary incontinence

Answer 27

atropine antagonist at muscarinic ACh receptor

Question 28

oxybutynin

Answer 28

M3 selective mAChR used in disorders of GU tract -reduce urinary frequency