Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CPR II Exam 2 > Drugs for Pulmonary HTN > Flashcards

Drugs for Pulmonary HTN Flashcards

1
Q

Who is the common demographic for pulmonary arterial HTN?

A

young women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the definition of pulmonary arterial HTN?

A

sustained elevation of mean pulmonary arterial pressure >25mmHg at rest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the common s/s of pHTN?

A

DOE, fatigue, chest pain, tachycardia,

syncope/near-syncope, edema, cyanosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the first gene linked to pHTN?

A

BMPR2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What common drug causes weight loss and pHTN?

A

fen/phen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the vasopressor test?

A

short acting vasodilator is administered

test is positive if PAP falls >10

MPAP <40

CO is unchanged or increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Some positive responders to the vasopressore test will achieve sustained functional improvement and prolonged suvival with what drug?

A

CCB

but will be deleterious in non-responders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What drugs do not help pHTN?

A

anticoagulants

diuretics

O2 therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the MOA of prostanoids?

A

promotes vascular relaxation

increases cAMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the effects of prostanoids?

A

lowers pulmonary arterial resistance

decreases pulmonary arerial pressure

increases exercise tolerance

improves survival

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Epoprostenol has a (short or long) half life?

A

short half life

must be given by IV continuously and kept cold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are some serious adverse effects of epoprostenol?

A

sepsis

life-threatening if pump problems ensue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the pharmokokinetics of treprostinil?

A

given SUBQ but caused too much pain, so given with IV pump

longer half life, no refrigeration

can do QID inhalation

extended release oral form avaialble

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the adverse effects for Treprostinil?

A

sepsis

jaw pain

cough/throat irritation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How is iloprost administered?

What are some adverse effects?

A

inhalation 6-9x per day

fainting from hyptension, jaw pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Selexipag is a prostanoid that can be administered (oral or IV)?

common adverse effect?

A

Orally, BID

is VERY expensive

Jaw pain

17
Q

Bosentan is an endothelin antagonist that blocks what?

A

blocks nonspecifically ETa and ETb receptors

18
Q

What are some toxicities of bosentan?

A

hepatotoxicity

teratogenesis

accelerates warfarin metabolism and oral contraception

19
Q

Ambrisentan is an endothelin antagonist that blocks what?

What are the main adverse reactions?

A

Eta selectively

teratogenesis, no liver damage, does not interfere with warfarin, but still must use 2 forms of birth control (due to teratogenesis)

20
Q

Macitentan is an endothelin antagonist that has what benefit?

A

18hr half life allowing for once/day dosing

21
Q

Silidenafil blocks what?

what can it cause if combined with a-blockers or nitrates?

A

selectively blocks PDE 5

can cuase significant hypotension

22
Q

What is the MOA of Riociguat?

A

sensistizes sGC to endogenous NO by stabilizing the NO-sGC

increases cGMP to increase vasodilation

23
Q

If a pt with confirmed pHTN and has a positive vasoreactivty test, treat with what?

A

CCB

24
Q

In patient with naive PHTN with WHO FC II and patient is able to tolerate combination therapy, treat with what?

If they are unable to tolerate combo therapy, treat with what?

A

Ambristentan and tadalafil

Macitentan, ambisentan, riocguat, sildenafil, or tadalafil

25
Q

In pt with naive PAH with WHO FC III w/o evidence of rapid dz progression who is able to take combo theraoy, treat with what?

If unable to take combo therapy?

A

Abrisentan an Tadalfil

Monotherapy with macitentan, ambisentan, riociguat, sildenafil, or tadalafil

26
Q

In pt with naive PHTN with WHO FC III with evidence of rapid dz progression and able to take parenteral prostanoids, treat with

IF unable to take parental prostanoids, take

A

IV epoprosteonol, IV treprostinil, or SC treprostinil

inhlaed or oral prostanoid

27
Q

In pt with pHTN with WHO FC IV and able to take parenteral prostanoids, treat with waht?

If unable to take parentarel prostenoids, tx with

A

IV epoprostenol, IV treprostinil, or SC treprostinil

inhaled prostanoid + oral PDE5 inhibitor and oral ET antagonist

28
Q

What is the most common pHTN drug combo?

A

Tadalafil + Ambrisentan

29
Q

What are the prostanoids?

A

Epoprostenol

treprostinil

iloprost

selexipag

30
Q

What are the PDE5 inhibitors

A

sildenafil

tadalafil

31
Q

what are the endothelin antagonists?

A

bosentan

ambrisentan

macicentan

32
Q

What is the guanylate cyclase sensitizer

A

riociguat

CPR II Exam 2 (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions