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Immunology AB > Drugs in Immunology AB > Flashcards

Drugs in Immunology AB Flashcards

(22 cards)

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1
Q

Icatiband - mechanism?

A

Bradykinin inhibitor

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2
Q

Aprepitant - mechanism?

A

Neurokinin 1 receptor / substance P antagonist

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3
Q

Alemtuzumab - mechanism?

A

Anti-CD52

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4
Q

Natalizumab - mechanism?

A

Recombinant humanised monoclonal antibody to alpha‑4 integrins

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5
Q

Eculizumab - mechanism and indications?

A

Anti-C5

PNH

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6
Q

Anakinra - mechanism?

A

Soluble IL-1 receptor antagonist

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7
Q

Tocilizumab - mechanism and indications?

A

IL-6 receptor antagonist

RA, Takayasu

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8
Q

Abatacept - mechanism?

A

CTLA1 Ig. Acts as a decoy binding B7 *CS80/86) on MHC

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9
Q

Rituximab - mechanism?

A

Anti-CD20

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10
Q

Tofacitinib - mechanism and indications?

A

JAK1/3 inhibitor

RA

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11
Q

Basiliximab - mechanism?

A

Against IL‑2 receptors expressed on activated human T lymphocytes; blocks binding of interleukin‑2, inhibiting T lymphocyte proliferation.

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12
Q

Secukinumab - mechanism and indications?

A

Anti-IL-17a

Ank Spond

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13
Q

Ustekinumab - mechanism and indications?

A

Against shared subunit of IL-12/23. Inhibits Th1/Th2 pathway

Psoriatic arthritis

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14
Q

Apremilast - mechanism and indications?

A

Oral small molecule inhibitor of PDE4 enxyme
Modulates production of inflammatory mediators at the level of mRNA

Psoriatic arthritis

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15
Q

Lebrikizumab - mechanism and indications?

A

Anti-IL-13

Th2 Asthma

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16
Q

Omalizumab - mechanism?

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A

Forms complexes with free IgE

17
Q

Ipilimumab - mechanism and indications?

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A

CTLA4 Ab

Indications: melanoma, ovarian ca, prostate ca, RCC

18
Q

Belimumab - mechanism and indications?

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A

Blocks soluble BAFF

SLE

19
Q

Atacicept - mechanism and indications?

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A

TACI-Ig
Blocks both BAFF and APRIL
Inhibits B cells

B cell malignancies

20
Q

Tabalumab - mechanism?

21
Q

Blisbimod

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A

BAFF-R-Ig fusion protein

22
Q

Brentuximab - mechanism and indications?

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A

Anti-CD30 bound to a toxin

Hodgkin lymphoma as CD30 is expressed on these cells but limited expression on normal cells

Immunology AB (4 decks)

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