Hypersensitivity AB

Question 1

What are 4 examples of type 1 hypersensitivity reactions?

Answer 1

Atopy
Asthma
Angioedema
Anaphylaxis

Question 2

What are 4 examples of type 2 hypersensitivity reactions?

Answer 2

Transfusion reactions
Rheumatic heart disease
Anti-GBM disease
Hashimoto’s

Question 3

What are 4 examples of type 3 hypersensitivity reactions?

Answer 3

Serum sickness 
Rheumatoid arthritis
SLE
Glomerulonephritis/vasculitis 
Extrinsic allergic alveolitis

Question 4

What are 4 examples of type 4 hypersensitivity reactions?

Answer 4

Mantoux reaction
Chronic transplant rejection
Multiple sclerosis
SJS/TEN
DRESS
Contact eczema

Question 5

What is the mechanism of hypersensitivity in type 1 hypersensitivity?

Answer 5

IgE is bound to mast cells. Allergens bind, cause cross-linking of IgE which induces degranulation

Question 6

What is the mechanism of hypersensitivity in type 2 hypersensitivity?

Answer 6

Cells are destroyed by bound antibody, either by:

1. Activation of complement
2. A cytotoxic T cell with an Fc receptor for the antibody (ADCC)

Question 7

What is the mechanism of hypersensitivity in type 3 hypersensitivity?

Answer 7

Ag-Ab complexes are deposited in tissue, causing activation of complement