Drugs: Mitosis Inhibitors (M phase drugs) Flashcards
(6 cards)
drugs ending in -tine or -taxel inhibit what
microtubules
Vincristine
Vinblastine
prevent polymerization of microtubules (mitotic spindles)
side effect of Vincristine
neurotoxic
side effect of Vinblastine
myelosuppression (no neurotoxicity)- bone marrow doesn’t make enough blood cells or platelets
Paclitaxel
Docetaxel
prevents depolymerization of microtubules (mitotic spindles)
side effect of paclitaxel and docetaxel
neurotoxic