Drugs: Protein Kinase Inhibitors Flashcards
(6 cards)
drugs ending in -nib inhibit
protein kinase
Imatinib
targets BCR-ABL
inhibits tyrosine kinase
BCR-ABL gene is associated with 2 things:
- leukemia
- philadelphia chromosome (9 to 22)
Erlotinib
Gefitinib
[E and G]
inhibition of tyrosine kinase domain of EGFR
these 2 growth factors promote tumor angiogenesis (formation of new blood vessels)
VEGF and PDGF
Dabrafenib
VEGF/PDGF receptor blocker
Ras/MEK inhibitor
blocks MAPK pathway