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MRCP > Drugs S/E > Flashcards

Drugs S/E Flashcards

1
Q

Phenytoin

A

Gingival hyperplasia
Hirsutism
Megaloblastic anaemia
Peripheral neuropathy
Osteomalacia
Coarsening of facial features

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2
Q

Leflunomide

A

DMARD
Hypertension
Peripheral neuropathy
Myelosuppression

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3
Q

Drugs causing urticaria

A

Penicillins
NSAIDs
Aspirin
Opioids

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4
Q

Cisplatin

A

Ototoxicity
Peripheral neuropathy
Hypomagnesaemia

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5
Q

Cyclophosphamide

A

Haemorrhagic cystitis
TCC
Myelosuppression

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6
Q

Bleomycin

A

Lung fibrosis

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7
Q

Doxorubicin

A

Cardiomyopathy

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8
Q

Methotrexate

A

Myelosuppression
Lung fibrosis
Liver fibrosis
Mucositis

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9
Q

Vincristine

A

Peripheral neuropathy
Paralytic ileus

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10
Q

Docetaxel

A

Neutropaenia

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11
Q

Causes of Stevens-Johnson Syndrome

A

Penicillin
Co-trimoxazole
sulphonamides
Lamotrigine, carbamazepine, phenytoin
Allopurinol
NSAIDs
COCP

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12
Q

Rifampicin

A

Hepatitis
Orange secretions

Liver enzyme inducer

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13
Q

Ethambutol

A

Optic neuritis

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14
Q

Pyrazinamide

A

Gout (pyramid-like crystals)

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15
Q

Isoniazid

A

Peripheral neuropathy

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16
Q

Ciprofloxacin

A

Tendinopathy

17
Q

Medications contra-indicated in Wolff-Parkinson-White
?why

A

Avoid ABCD
Adenosine, beta blockers, Calcium channel blockers, digoxin -> risk of VF

SAFe medications
Sotalol unless A.fib, amiodarone, flecainide

18
Q

Medications contra-indicated in Wolff-Parkinson-White
?why

A

Avoid ABCD
Adenosine, beta blockers, Calcium channel blockers, digoxin -> risk of VF

SAFe medications
Sotalol unless A.fib, amiodarone, flecainide

19
Q

Tacrolimus

A

Tremor

20
Q

Drug induced pancytopaenia

A

Cytotoxics
Trimethoprim, chloramphenicol
Carbimazole
anti-epileptics: carbamazepine
Sulphonylureas: tolbutamide

21
Q

Ciclosporin - level monitoring timing

A

Trough level

22
Q

Lithium - blood level range, monitoring timing

A

range = 0.4 - 1.0 mmol/l
take 12 hrs post-dose

23
Q

Digoxin - level monitoring timing

A

At least 6 hours post-dose

24
Q

Phenytoin

levels

A

Trough levels only if: dose adjusted, suspected toxicity, suspected non-adherence

25
Q

Botulinum indications

A

blepharospasm
hemifacial spasm
focal spasticity - cerebral palsy, stroke
spasmodic torticollis
severe hyperhidrosis of axilla
achalasia

26
Q

Ticagrelor

A

Dyspnoea

27
Q

Aromatase inhibitors

A

Osteoporosis

28
Q

Thiazides

A

Photosensitivity

29
Q

Erythematous macules -> blisters
Oral involvement
<10% of body surface area

A

Stevens Johnson syndrome

MRCP (19 decks)

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