Drugs Used In Coagulation Disorders

Question 1

refers to the finely regulated dynamic process of maintaining fluidity of the blood, repairing vascular injury, and limiting blood loss while avoiding vessel occlusion and inadequate perfusion of vital organs

Answer 1

Hemostasis

Question 2

vessel occlusion

Answer 2

thrombosis

Question 3

the cessation of blood loss from a damaged vessel

Answer 3

Hemostasis

Question 4

compensatory mechanism to prevent/reduce blood loss

Answer 4

vascular spasm

Question 5

product is fibrin

Answer 5

blood clot formation

Question 6

blood clot formation is synonymous to

Answer 6

coagulation cascade

Question 7

Common causes of dysregulated hemostasis

Answer 7

1. hereditary or acquired defects in the clotting mechanism
2. secondary effects of infection or cancer

Question 8

intricately balanced and designed to stop bleeding at the site of vascular injury

Answer 8

Coagulation system

Question 9

T/F: The coagulation system is intricately balanced and designed to stop bleeding at the site of vascular injury through complex interactions between the vascular endothelium, platelets, procoagulant proteins, anticoagulant proteins, and fibrinolytic proteins.

Answer 9

True

Question 10

Three key mechanisms that facilitate hemostasis

Answer 10

1. vascular constriction
2. primary platelet plug formation (primary hemostasis)
3. clot propagation through fibrin formation (secondary hemostasis)

Question 11

platelets that circulate in the blood

Answer 11

inactivated platelets

Question 12

type of platelets in the presence of injury

Answer 12

activated platelets

Question 13

initial phase of the blood coagulation process

Answer 13

vascular constriction

Question 14

limits the flow of blood to the area of injury

Answer 14

vascular constriction

Question 15

absolutely required for hemostasis to proceed

Answer 15

Activation of platelets

Question 16

Platelets become activated by _________

Answer 16

thrombin

Question 17

Activated platelets aggregate at the site of injury, forming a _________________________________.

Answer 17

temporary, loose platelet plug

Question 18

Platelets clump by binding to ___________ that becomes exposed following rupture of the endothelial lining of vessels.

Answer 18

collagen

Question 19

forms and entraps the plug to ensure the stability of the initially loose platelet plug

Answer 19

fibrin mesh

Question 20

fibrin mesh is aka

Answer 20

clot

Question 21

released by endothelial cells in response to injury

Answer 21

von Willebrand factor (vWF)

Question 22

act as bridge for platelets to adhere to collagen

Answer 22

von Willebrand factor (vWF)

Question 23

T/F: Once platelet attaches to collagen through the vWF, it becomes activated

Answer 23

True

Question 24

GP1b receptor is found in ?

Answer 24

the platelet

Question 25

vWF would attach to this receptor to adhere platelet to collagen

Answer 25

GP1b receptor

Question 26

vWF deficiency or lack of mesh formation would result to

Answer 26

bleeding

Question 27

overdose of anti-platelet drug

Answer 27

bleeding

Question 28

T/F: Major side effect of anti-platelet drug is always bleeding

Answer 28

True

Question 29

precursor of TXA2

Answer 29

cyclooxygenase

Question 30

action of this receptor is vasoconstriction to prevent blood loss

Answer 30

5-HT receptor

Question 31

active fibrinolytic enzyme

Answer 31

Plasmin

Question 32

a combination of streptokinase and the proactivator plasminogen

Answer 32

Anistreplase

Question 33

inhibits the activation of plasminogen to plasmin and is useful in some bleeding disorders

Answer 33

Aminocaproic acid

Question 34

What coagulation factor is used to produce fibrin clot?

Answer 34

Factor I (Fibrinogen)

Question 35

What coagulation factor is used to produce thrombin needed for the conversion of fibrinogen to fibrin?

Answer 35

Factor II (Prothrombin)

Question 36

Factor II (Prothrombin) target the actions of what

Answer 36

heparin, dabigatran, warfarin (synthesis)