DTP Magnesium Sulfate

Question 1

Drug Class

Answer 1

Electrolyte

Question 2

Pharmacology

Answer 2

• Inhibits smooth muscle contraction
• • Causes vasodilation and bronchodilation
• Possess anticonvulsant and anti-dysrrhythmic properties

Question 3

Metabolism

Answer 3

filtered in the kidneys and excreted predominantly

in urine with small amounts in faeces and saliva

Question 4

Indications

Answer 4

• Box jellyfish envenomation (unresponsive to antivenom therapy)
• Eclampsia
• Irukandji syndrome (with intractable pain
unrelieved by narcotic analgesia AND/OR systolic
BP > 160 mmHg)
• Torsades de Pointes
• Severe life-threatening asthma (only in patients
who have required IV salbutamol AND/OR IM/IV
adrenaline)

Question 5

Contraindications

Answer 5

• KSAR
• Heart block
• Renal failure

Question 6

Precautions

Answer 6

Renal impairment

Question 7

Side effects

Answer 7

• Pain at the cannulation site
• Magnesium toxicity
– hypotension/respiratory depression
– loss of deep tendon reflexes

Question 8

Presentation

Answer 8

Ampoule, 10 mmol (2.47 g)/5 mL

Question 9

Onset (IV)

Answer 9

Immediate

Question 10

Duration (IV)

Answer 10

30 minutes

Question 11

Half-life (elimination

Answer 11

Variable

Question 12

Schedule

Answer 12

Unscheduled.

Question 13

Adult dose for Irukandji syndrome (with intractable pain unrelieved by narcotic analgesia AND/OR systolic BP > 160 mmHg)

Answer 13

IV Loading dose – 20 mmol
Slow push over 15 minutes.

IV infusion maintenance dose (listed below) is to be administered immediately following IV loading dose.

IV INF
Maintenance infusion – 20 mmol over 60 minutes

Question 14

Adult dose for Box Jellyfish envenomation (unresponsive to antivenom therapy)

Answer 14

IV 20 mmol
Slow push over 15 minutes.
SPRINGFUSOR ® use is highly recommended.
Single dose only.

Question 15

Paediatric dose for Irukandji and Box Jelly fish

Answer 15

• IV 0.1 mmol/kg (rounded up to the nearest 0.5 mmol)
• Slow push over 15 minutes.
• SPRINGFUSOR ® use is highly recommended.
• Single dose not to exceed 5 mmol.
• Repeated once at 10 minutes.
• Total maximum dose 10 mmol.

Question 16

Special Notes

Answer 16

Irukandji syndrome is decribed as a tropical sting
(usually minimal discomfort) followed in 15 – 40 minutes of significant systemic symptoms of pain, agitation, restlessness, and clinically associated with signs of catecholamine excess