DTP Metoclopramide (Maxalon)

Question 1

Drug class: Metoclopramide

Answer 1

Antiemetic

Question 2

Pharmacology of Metoclopramide

Answer 2

• a dopamine receptor antagonist
• inhibits gastric smooth muscle relaxation
• accelerates GI transit and gastric emptying
• raises the chemoreceptors threshold in the floor of the fourth ventricle.

Question 3

Indications for metochlopramide

Answer 3

1. Significant nausea / vomiting

2. Prophylactic use with pts who have Hx of nausea / vomiting with narcotic administration.

Question 4

Contraindications for metochlopramide

Answer 4

1. KSAR
   2, patients < 16 years
2. Hx of dystonic reaction
3. Pts whom have had phenothiazines in the last 6 hrs

Question 5

Precautions for metochlopramide

Answer 5

1. GI haemorrhage

2. Pts with bowel obstruction / perforation

Question 6

Side effects for metochlopramide

Answer 6

1. Drowsiness / lethargy
2. Dry mouth
3. Dystonic reaction
4. Occulogyric crisis

Question 7

Presentation of metochlopramide

Answer 7

10 mg in 2 mls

Question 8

Onset of metoclopramide

Answer 8

1-3 mins IVI

10-15min IMI

Question 9

Schedule for metochlopramide

Answer 9

S4 restricted drugs

Question 10

Doses for metochlopramide

Answer 10

10-20 mg IMI and IVI ( slow push for 1-2 mins )

Question 10

Duration of metochlopramide

Answer 10

1-2 hrs

Question 11

Half life of metoclopramide

Answer 11

2.5 - 5 hrs