Dyslipidemia Flashcards
(13 cards)
What are the primary lipid lowering medications
Statins
Ezetimibe
PCSK-9 inhibitors
Bile acid sequesterents
What are the primary groups that benifit from statin therapy
1) Clinical ASCVD
2) LDL >190
3)DM
4) Primary prevention
What are the 2 high-intensity lowering statins
Rosuvastatin (20-40 mg)
Atorvastatin (40-80 mg)
Lowers LDL by >50%
Which statin needs to be taken with food to help it absorb
lovastatin (all others you don’t take with food)
What is a common drug drug interaction with statins
Grapefruit juice (1 liter causes a clinically relevent reaction).
Red yeast rice also acts similarly
What are the 4 statin benefit groups
Prevention of ASCVD
DM
Secondary prevention with clinical ASCVD
If a patient is on Rosuvastatin 40mg and his LDL remains at 150, what is the appropriate treatment
Add ezetimibe
MOA for ezetimibe
Cholesterol absorption inhibitor–> Decrease LDL and TG
Dose= 10mg PO qd
Reduce LDL by 20%, Raise HDL by 1%
Contraindications: Severe Liver disease if taken with statins
Consider if unable to achieve desired response to intolerance
PCSK9 inhibitors Important information
Very costly and not typically insurance covered
Adjunct use to statins
Shot- SC q 2 weeks
Bile-Acid sequestarants key points
Safe in pregnancy
Consider this medication if intolerant to other therapies
Bempedoic Acid MOA and key points
Inhibits ACL –> cholesterol synthesis in liver
Very expensive, can cause URI or anemia, can use in combo form with ezetimibe
Inclisaran MOA
SiRNA targetting PCSK9, inhibits PCSK9 liver production, prolongs activity in LDL receptors
SC ROA
MOA for Fibrates
Agonist for PPAR alpha receptor–>Downregulates lipoprotein lipase–>clear VLDL–>clear triglycerides
