Dyslipidemia Agents

Question 1

Cholestyramine, Colestipol, and Colesevelam are all ________

Answer 1

Bile Acid Sequestrants

“Shop at Kohl’s to sequester your bile”

Question 2

Omega 3’s are mainly used to lower ______

Answer 2

TGs

Question 3

Mipopmersen Mnemonic

Answer 3

“Me pop the Apo Synthesis”

Question 4

Statins AND Bile Sequestrants are useless for ____ ______

Answer 4

Familial Hypercholesteremia

Question 5

3 most potent Statins

Answer 5

1. Atorvatatin
2. Rosuvastatin
   Simvastain

Question 6

Bile Acid Binding Resins Dual MOA

Answer 6

1. Bind Bile Acid to prevent reabs

2. Upreg LDL receptors

Question 7

Lomitapide MOA

Answer 7

Microsomal Triglyceride Transfer Protein Inhibitor
- MTP inhib results in less VLDL secretion
- Less LDL
“Dangerous Palomita flies away with Triglyceride Transporter”

Question 8

Evolocumab and Alirocumab are both _______ Inhibitors

Answer 8

PCSK9

Question 9

What class of drugs is Ezetimibe?

Answer 9

Cholesterol Transporter Inhibitors

Question 10

What is NPC1L1?

Answer 10

Cholesterol transporter into Liver

Question 11

Evolocumab and Alirocumab MOA and Indication

Answer 11

Block PSCK9

• Evo for Familial Hypercholesteremia
• Ali JUST for lowering LDL

Question 12

Aside from Gastro probs, 2 Side effects of Lomitapide (MTP inhib)

Answer 12

1. Lower HDL

2. Liver problems

Question 13

Dual MOA of Omega 3’s

Answer 13

1. Reduce VLDL TG synth

2. Boost Fatty oxidation

Question 14

Ezetimibe dual MOA

Answer 14

1. Block NPC1L1 Cholesterol transport

2. Boost LDL receptors

Question 15

Gemfibrozil and Fenofibrate are 1st line treatment for _______

Answer 15

Hypertriglyceridemia

especially with low HDL pts

Question 16

Mipopmersen Antisense ApoB100 inhibitor adverse effects.

Answer 16

1. Flu-like symptoms
2. Fatty Liver
   (REMS)

Question 17

Mipopmersen indication

Answer 17

Homo Fam Hyper Cholest.

Question 18

Statins Dual MOA

Answer 18

1. Inhibit HMG-CoA Reductase

2. Upreg LDL Receptors

Question 19

Eicosapentaenoic Acid and Docosahexaenoic acid are both ____ ____ ____

Answer 19

Long Chain Omega 3’s

Question 20

Adverse effect of Niacin?

Answer 20

Hepatotoxicity

Question 21

I call Gemfibrozil and Fenofibrate the “_____s and ______s”. Because Fine Fiber is a Gem of a Find to lower ______s

Answer 21

“Choppers and Stoppers”

- TGs

Question 22

Lomitapide the MTP inhibitor is only use to treat _______

Answer 22

Familial Hypercholest

Question 23

What is Ninja Niacin’s Triple MOA?

Answer 23

1. Inhibit FA release/Synth
2. Activate LPL lipsae
3. Protect HDLS (boost 14-39%)

Question 24

What drug inhibits NPC1L1 Cholesterol transporter?

Answer 24

Ezetimibe

“Robot Zet lowers the Transporter’s Vibe)

Question 25

Microsomal Triglyceride Transfer Protein Purpose

Answer 25

Adds TGs to VLDLs and Chylos to make LDLs

Question 26

Two Fibric Acid Derivative "Chopper and Stoppers"

Answer 26

1. Gemfibrozil | 2. Fenofibrate

Question 27

Aside from GI effects, what's a possible negative consequence of Bile Sequestrants that means you need to be mindful when prescribing to patients?

Answer 27

``` Boost TGs (Avoid Hypertrigly patients >250mg/dL) ```

Question 28

Name the 3 Bile Acid Sequestrants

Answer 28

1. Cholestyramine 2. Colestipol 3. Colesevelam

Question 29

Gemfibrozil and Fenofibrate Triple MOA

Answer 29

1. PPAR-alpha Fatty oxidation 2. LPL Boost 3. Reduce apoC3

Question 30

Use statins when LDLs are more than _____mg/dL

Answer 30

190

Question 31

2 Side effects of Statins

Answer 31

1. Hepatotox 2. Myopathy (Watch ALT levels)

Question 32

What is PCSK9?

Answer 32

Protease that cops LDLR and boosts LDLs | "Pesky Choppers"

Question 33

Name of the Antisense APO-B100 inhibitor

Answer 33

Mipopmersen

Question 34

Mipopmersen MOA

Answer 34

Antisense Inhibit Apo-B100 to lower LDL