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Finals_Ther 202 > E02_07 Diabetes > Flashcards

E02_07 Diabetes Flashcards

1
Q

2017, 2018_Diabetes

Based on efficacy criteria, which among the following drugs is considered the most effective in lowering HbA1c?

A. Megletinides/glinides
B. DPP4 inhibitors
C. Biguanides
D. Thiazolidinediones

A

C. Biguanides

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2
Q

2017, 2018_Diabetes

Which of the following drugs causes the most episodes of hypoglycemia?

A. Biguanides
B. Thiazolidinediones
C. Meglitinides
D. Sulfunylureas

A

D. Sulfunylureas

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3
Q

2017, 2018_Diabetes

You have a newly diagnosed 57 year old diabetic patient with an estimated GFR of 20. Which of the following drugs is contraindicated?

A. Insulin
B. DPP4 inhibitors
C. Metformin
D. Meglitinides/glinides

A

C. Metformin

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4
Q

2017, 2018_Diabetes

The usual starting dose of Metformin is:

A. 500 mg 3x a day before eating
B. 500 mg 3x a day after eating
C. 500 mg 2x a day before eating
D. 500 mg x2 a day after eating

A

D. 500 mg x2 a day after eating

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5
Q

2017, 2018_Diabetes

You have a 48 year old patient who is consulting you for the first time for diabetes. His FBS is 2– mg/dL and his HbA1c is 92%. According to the Philippine guideline your P-drug for this patient will be which of the following?

A. Sulfunylureas
B. Metformin
C. Combination therapy of 2 anti-diabetic drugs
D. Basal insulin alone

A

C. Combination therapy of 2 anti-diabetic drugs

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6
Q

2017, 2018_Diabetes

Which of the following drugs has a glucose dependent mechanism of action for suppression of glucagon and stimulates insulin production?

A. Megletinides/glinides
B. Biguanides
C. Incretin or incretin-based therapy
D. Thiazolidinediones

A

C. Incretin or incretin-based therapy

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7
Q

2017_Diabetes

You have a patient with diabetes with a BMI of 32 kg/m2. Which of the following drugs is the best treatment due to its side effect of weight loss?

A. DPP4 inhibitors
B. Sulfonylureas
C. Thiazolidinediones
D. Incretins

A

D. Incretins

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8
Q

2017, 2018_Diabetes

Your 62 year old diabetic patient is currently consulting for bipedal edema ans easy fatiguability. You suspect CHF and upon audit of his medications you decided to remove one of them. Which of the following is the drug you will most likely remove from his prescription?

A. Pioglitazone
B. Repaglinide
C. Sitagliptin
D. Glicazine

A

A. Pioglitazone

AE of Thiazolidinediones (e.g. Pioglitazone) - CHF, Edema, Bone Fractures, Bladder CA, weight gain

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9
Q

2017_Diabetes

Which of the following are long acting second generation sulfunylureas?

A. Glibenclamide
B. Chlorpropamide
C. Nateglinide
D. Glimepiride

A

A. Glibenclamide

*Answer key says D. Glimepiride
Glimepiride is 3rd gen in some references, medium- to long-acting

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10
Q

2017, 2018_Diabetes

Example of a drug that work by inhibiting the SGLT-2 in the proximal convoluted tubule of the kidneys:

A. Repaglinide
B. Dapaglifozin
C. Sitagliptin
D. Rosiglitazone

A

B. Dapaglifozin

Glinides = Meglitinides
Gliflozins = SGLT2
Gliptins = DPP4
Glitazones = TZDs
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11
Q

2017_Diabetes

Glycemic target for a 72 year old patient with a creatinine clearance of 24 ml/min, who has suffered a stroke and has right sided hemiparesis:

A. FBS of 180-200 mg/dL
B. HbA1c of

A

B. HbA1c of

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12
Q

2017_Diabetes

Drug of choice for a diabetic patient with hepatic failure due to chronic active hepatitis B:

A. DPP4 inhibitors
B. Alpha glucosidase
C. Insulin
D. SGLT-2 inhibitors

A

C. Insulin

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13
Q

2018_Diabetes

Which of the following guidelines considers patient values and preferences in deciding on the P drug?

A. American Diabetes Association - EASD
B. American Association of Clinical Endocrinology
C. International Diabetes Federation
D. Canadian Diabetes Association

A

A. American Diabetes Association - EASD

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14
Q

2018_Diabetes

Drug of choice as monotherapy for most patients with type 2 DM?

A. Metformin
B. Sulfonylureas
C. TZDs
D. DPP4 inhibitors

A

A. Metformin

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15
Q

2018_Diabetes

Which of the following agents is ideal for use in obese patients for its weight losing capacity?

A. DPP4 inhibitors
B. Sulfonylureas
C. Thiazolidinediones
D. SGLT2 inhibitors

A

D. SGLT2 inhibitors

> Weight loss:

  1. Biguanides
  2. SGLT2 Inhibitors
  3. GLP1 Receptor Agonists

> Weight gain:

  1. SU
  2. Meglitinides
  3. TZDs

*DPP4 (-gliptins) - weight neutral

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16
Q

2018_Diabetes

Which is the most expensive drug? 
A. NPH
B. Liraglutide
C. Sitagliptin
D. Gliclazide
A

B. Liraglutide - GLP1

From the lecture: 
Cost ranking
- GLP1 > SGLT2
- Insulin ~P12/day (including syringe, which is around P8 each) >> almost same as your Biguanides
- SUs are cheap
17
Q

2018_Diabetes

Which of the following drugs is currently listed in the Philippine National Formulary?

A. Gliclazide
B. Glibenclamide
C. Glimepiride
D. Insulin glargine

A

A. Gliclazide

18
Q

2018_Diabetes

Preferentially lowers postprandial blood sugar

A. Metformin
B. TZDs
C. DPP4 inhibitors
D. Meglitinide

A

D. Meglitinide

Finals_Ther 202 (21 decks)

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