Eicosanoids Flashcards Preview

26 Autacoids > Eicosanoids > Flashcards

Flashcards in Eicosanoids Deck (22)
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1

Eicosanoid synthesis inhibitors (3 groups)

Leukotriene inhibitors
NSAIDs
Corticosteroids

2

Prostaglandin E1 agonists (2 drugs)

Alprostadil
Misoprostol

3

Alprostadil - indications

Maintaining patent ductus arteriosis
Erectile dysfunction

4

Alprostadil - adverse effects

Penile pain & fibrosis, priapism

5

Misopristol - indications

NSAIDs treatment (prevent ulcers)
Abortifacient

6

Misoprisol is used as abortifacient with ...?

Mifepristone

7

Misopristol - contraindications

Pregnancy (cause uterine contractions)

8

Misopristol - adverse effects

Uterine contractions & premature labor

9

PGE2 analogue (1 drug)

Dinoprostone

10

PGF2alpha agonists (4 drugs)

Carbaprost tromethamine
Latanoprost
Bimatoprost
Travoprost

11

Dinopristone - indications

Labor induction - cervical ripening
Evacuate uterine contents

12

Dinopristone + Carbaprost tromethamine - MOA

Ocytocic activity - uterine contractions in pregnancy

13

Carbaprost tromethamine - indications

Postpartum bleeding
Abortifacient

14

Carbaprost tromethamine - adverse effects

Altered BP
Blurred vision
Respiratory distress

15

PGF agonists used for open angle glaucoma (3 drugs)

Latanoprost
Bimatoprost
Travoprost

16

PGF agonists used for ocular hypertension (2 drugs)

Bimatoprost
Travoprost

17

Prostacyclin analogues (2 drugs)

Epoprostenol
Treprostinil

18

PGI2 analogues - indications

Pulmonary arterial hypertenstion

19

Epoprostenol - adverse effects

Tachycardia, hypotension

20

Endothelin-1 antagonists (2 drugs)

Bosentan
Ambrisentan

21

Eicosanoid-associated drugs used for pulmonary arterial hypertension (4 drugs + their groups)

PGI2 analogues: epoprostenol, treprosteinil
ET antagonists: bosentan, ambrisentan

22

Bosentan - contraindications

Pregnancy