Antihistamines (H1 antagonists) Flashcards Preview

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Flashcards in Antihistamines (H1 antagonists) Deck (18)
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1

What groups of antihistamines are there?

4 generations
(Intranasal + ophthalmic)

2

Which antihistamine is most active for allergic reactions?

All are equally active for allergic reactions

3

1st generation antihistamines (8 drugs)

Chlorpheniramine
Clemastine
Dimenhydrinate
Diphenhydramine
Hydroxyzine
Meclizine
Promethazine
Doxepin.

4

1st generation antihistamines - adverse effects

Sedation
Children: cause excitement
Dry mouth
Blurred vision
Tachycardia
Urinary retention
Hallucinations

5

1st generation antihistamines with least sedating effect (1 drug)

Chlorpheniramine

6

1st gen antihistamines with highest sedating effect (3 drugs)

Dephenhydramine
Hydroxyzine
Promethazine

7

1st gen antihistamines used for vertigo and motion sickness (2 drugs)

Dimenhydrinate
Meclizine

8

1st gen antihistamines with higher incidence of adverse effects (2 drugs)

Diphenhydramine
Promethazine

9

1st gen antihistamines used for: Induce sleep, pre-op sedation, distress from severe pruritus (4 drugs)

Diphenhydramine
Hydroxyzine
Promethazine
Doxepin

10

Doxepin - indications (that are special for this drug)

Antidepressant, anxiolytic.

11

2nd gen antihistamines (4 drugs)

Cetrizine
Fexofenadine
Loratadine
Desloratadine

12

2nd gen antihistamines - indications

Allergic reactions

13

Which 2nd gen antihistamine can cause some sedation?

Cetrizine

14

Antihistamine for intranasal adm (1 drug)

Azelastine

15

Azelastine - indications

Allergic rhinits

16

Azelastine - adverse effects

Drowsiness
Fatigue
Nasal irritation
Dry mouth
Weight gain

17

Antihistamines for ophthalmic use (4 drugs)

Levocabastine
Epinastine
Olopatadine
Ketotifen

18

Ophthalmic antihistamines - indications

Allergic conjunctivitis