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Flashcards in Endo Drugs Deck (29)
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1

What is orlistat? What does it improve?

pancreatic lipase inhibitor
improves BP and lipid profiles

2

What reduces glucose absorption from the gut by preventing complex sugars from getting broken down? When to be given?

Acarbose
before meals

3

What is pioglitazone? Why is this bad but good?

thaizolidinediones
can take up to 12 wks to work but improved lipid profiles

4

What is Exenatide? How is it given?

GLP1 agonist
increases insulin ONLY when glucose is elevated
parenterally

5

What drug is insulin sensitizer on liver and muscle cell? Why is this drug good for DMII? Contraindicated in?

metformin
wt loss
kidney dz

6

Which drugs increase insulin secretion? Is it sulfo or nonsulfonylureas?

Glipizide - sulfonylurea
Repaglinide- nonsulfonylurea

7

What insulin is long acting? Onset? Duration?

Glargine
onset: 2-4hr
duration: 20-24hr

8

What insulin is intermediate acting? Onset? Duration?

NPH, isophane insulin
2-4hr; duration 10-16hr

9

What insulin is short acting? Onset?

regular insulin
30-60min

10

What are the 2 rapid acting insulin? Onset?

aspart
lispro
5-15min

11

Pt has initial a1c >9 -tx?

no sx: dual or triple therapy
sx: insulin

12

Pt has initial a1c of >7.5-tx?

lifestyle changes + dual therapy
-metformin + GLP, DPP4, Cromocriptine, AG

13

Pt has initial a1c of 7.5 or lower - tx?

lifestyle changes + monotherapy
-metformin
-GLP
-DPP4
-AG

14

What drug is contraindicated for pts w/ renal failure - DMII?

metformin

15

What is levothyroxine?

synthetic T4 so it can turn into T3

16

When should levothyroxine be taken?

empty stomach

17

What to be cautious about levothyroxine?

narrow therapeutic index so easy to make hyperthyroid or hypothyroid

18

How long does levothyroxine take to work?

4-6wks

19

ADR for aspart and lispro? Same as?

lipodystrophy
wt gain
same as reg insulin and glargine

20

ADR for Repaglinide?

CV risk
tolerance
SIADH

21

What antihyperglycemic has NO hypoglycemia?

biguanide/metformin
acarbose

22

ADR for metformin?

lactic acidosis

23

Who to avoid metformin in?

do not give to pts >80yo
GI prob
vitamine B12 def

24

ADR for exentaide?

acut epancreatitis

25

DI for exentaide?

warfarin
digoxin

26

ADR for acarbose?

flatulence and diarrhea
monitor LFT for liver toxicity

27

ADR for pioglitazone?

hepatoxicity -omnitor LFT
wt gain

28

ADR for orlistat/

vitamin A D E K def

29

DI for orlistat?

vitamin K
warfarin