Endo Drugs

Question 1

What is orlistat? What does it improve?

Answer 1

pancreatic lipase inhibitor

improves BP and lipid profiles

Question 2

What reduces glucose absorption from the gut by preventing complex sugars from getting broken down? When to be given?

Answer 2

Acarbose

before meals

Question 3

What is pioglitazone? Why is this bad but good?

Answer 3

thaizolidinediones

can take up to 12 wks to work but improved lipid profiles

Question 4

What is Exenatide? How is it given?

Answer 4

GLP1 agonist
increases insulin ONLY when glucose is elevated
parenterally

Question 5

What drug is insulin sensitizer on liver and muscle cell? Why is this drug good for DMII? Contraindicated in?

Answer 5

metformin
wt loss
kidney dz

Question 6

Which drugs increase insulin secretion? Is it sulfo or nonsulfonylureas?

Answer 6

Glipizide - sulfonylurea

Repaglinide- nonsulfonylurea

Question 7

What insulin is long acting? Onset? Duration?

Answer 7

Glargine

onset: 2-4hr
duration: 20-24hr

Question 8

What insulin is intermediate acting? Onset? Duration?

Answer 8

NPH, isophane insulin

2-4hr; duration 10-16hr

Question 9

What insulin is short acting? Onset?

Answer 9

regular insulin

30-60min

Question 10

What are the 2 rapid acting insulin? Onset?

Answer 10

aspart
lispro
5-15min

Question 11

Pt has initial a1c >9 -tx?

Answer 11

no sx: dual or triple therapy

sx: insulin

Question 12

Pt has initial a1c of >7.5-tx?

Answer 12

lifestyle changes + dual therapy

-metformin + GLP, DPP4, Cromocriptine, AG

Question 13

Pt has initial a1c of 7.5 or lower - tx?

Answer 13

lifestyle changes + monotherapy

• metformin
• GLP
• DPP4
• AG

Question 14

What drug is contraindicated for pts w/ renal failure - DMII?

Answer 14

metformin

Question 15

What is levothyroxine?

Answer 15

synthetic T4 so it can turn into T3

Question 16

When should levothyroxine be taken?

Answer 16

empty stomach

Question 17

What to be cautious about levothyroxine?

Answer 17

narrow therapeutic index so easy to make hyperthyroid or hypothyroid

Question 18

How long does levothyroxine take to work?

Answer 18

4-6wks

Question 19

ADR for aspart and lispro? Same as?

Answer 19

lipodystrophy
wt gain
same as reg insulin and glargine

Question 20

ADR for Repaglinide?

Answer 20

CV risk
tolerance
SIADH

Question 21

What antihyperglycemic has NO hypoglycemia?

Answer 21

biguanide/metformin

acarbose

Question 22

ADR for metformin?

Answer 22

lactic acidosis

Question 23

Who to avoid metformin in?

Answer 23

do not give to pts >80yo
GI prob
vitamine B12 def

Question 24

ADR for exentaide?

Answer 24

acut epancreatitis

Question 25

DI for exentaide?

Answer 25

warfarin | digoxin

Question 26

ADR for acarbose?

Answer 26

flatulence and diarrhea | monitor LFT for liver toxicity

Question 27

ADR for pioglitazone?

Answer 27

hepatoxicity -omnitor LFT | wt gain

Question 28

ADR for orlistat/

Answer 28

vitamin A D E K def

Question 29

DI for orlistat?

Answer 29

vitamin K | warfarin