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Flashcards in HemOnc Drugs Deck (14):
1

ADR of ASA?

GI ulcers
Reye sx in kids

2

What is a type of antiplatelet?

clopidogrel

3

How does clopidogrel work?

antiplatelet
works well w/ASA
inhibits platelet activation

4

What is an anticoagulant? How to monitor?

warfarin
monitor: PT/INR

5

What are anticoagulation agent?

unfractionated heparin
LMWK-enoxaparin
direct factor Xa inhibitor - rivaroxaban
direct thrombin inhibitor - dabigatran

6

How to monitor unfractionated heparin? Reverse? ADR?

aPTT
reverse w/ protamine
HIT

7

What is good about enoxaparin? Reverse?

LMWH
-more selective = more predictable
-longer half life
reverse: partially w/ protamine

8

Which turn off factor Xa?

unfractionated heparin
enoxaparin
rivaroxaban

9

What is bad about rivaroxaban?

no antidotes to reverse

10

What is good about dabigatran?

no lab monitoring needed

11

What is dabigatran?

anticoagulant
-direct thrombin inhibitor

12

What is 5-flurouracil? ADR?

fakes like a purine/pyrimidine by preventing DNA replication
ADR: cardiotoxic, alopecia, pancytopenia

13

What is methotrexate?

stops folic acid reductase

14

What to keep in mind about folic acid?

can mask b12 def