Endocrine

Question 1

Crotisol to cortisone converting enzyme

Answer 1

11 beta hydroxy steroid dehydrogenase type 2

Cortisol has both glucocorticoid and mineralocorticoid actions. Cortisone is inactivated form with only gc action

Question 2

Pseudocushings seen in

Answer 2

Obese
Depression
Alcoholics

Due to chronic stress

Question 3

Cushings ds vs cushings syndrome

Answer 3

Cushings syndrome has all the symptoms like moon facies, purple striae, buffalo hump, central obesity, proximal muscle weakness, hypertension, easy bruising

Cushing disease is pituitary adenoma

Question 4

Infection with eosinopenia is____
Non-infection with eosinopenia is__

Answer 4

1.typhoid
2.cushings syndrome

Question 5

Actions of cortisol in cushings

Answer 5

1.protein - main
Protein catabolism… but actually mainly reduced protein anabolism in extrahepatic tissue. Aminoa cids uptake is reduced in extrahepatic tissues so proximal myopathy and increased in liver. So aa in blood increases, ie, alanine also increase in blood which is a main substrate for gluconeogenesis… taken up by liver.. thus increasing blood sugar level.

2.fat-mainly fat distribution and minimal lipolysis(which also increase blood sugar by gluconeogenesis

3.carohydrate - adrenal diabetes d/t lipolysis and alanine gluconeogenesis

4.mineralocorticoid action - triad : htn, alkalosis, hypokalemia

5.sex steroid action- acne, hirsuitism, amenorrhea/oligomenorrhea

6.cns - depression, steroid induced psychosis(rare)