Endocrine 2 Flashcards
steroids from least to greatest in antiinflammatory effects
hydrocortisone
prednisone
methylprednisolone
fludrocortisone
dexamethasone
betamethasone
“happy people make fun during break”
describe Chrousos syndrome
primary generalized glucocorticoid resistance
issue with glucocorticoid receptor
rare and genetic
compesation: ^ACTH > HTN, K imbalances, hyperandrogenism
med to treat chrousos syndrome?
dexamethasone because of not Na retaining effects
how to treat aldosteronism?
spironolactone
where are mineralcorticoid receptors?
DCT and CD of kidney
where does mineralcorticoids cause Na retention?
sweat, salivary glands, GI mucosa
and kidney
what two things control aldosterone production?
50% ACTH
50% Angiotensin
how are mineral corticoids excreted?
conjugated tetrahydroaldosterone in the urine
what is endogenous precursor to aldosterone?
deoxycorticosterone
what primarily controls deoxycorticosterone secretion?
ACTH
can fludorocortisone bind both GR and MR?
yes
What non adrenal issues can glucocorticoids be used in?
allergic
GI
inflamatory
transplant
pulm
allergic uses of glucocorticoids?
angioneurotic edema, asthma, bee sting, contact dermatitis, drug reactions, allergic rhinitis, serum sickness, urticaria
GI uses of glucocorticoids?
inflammatory bowel disease, nontropical spruce (Celiac), subacute hepatic necrosis
anti-inflammatory uses of glucocorticoids?
in bones and joints
arthritis, bursitis, tensosynovitis