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Pharmacology 1 Brandon's additional Cards > Endocrine 2 > Flashcards

Endocrine 2 Flashcards

1
Q

steroids from least to greatest in antiinflammatory effects

A

hydrocortisone
prednisone
methylprednisolone
fludrocortisone
dexamethasone
betamethasone

“happy people make fun during break”

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2
Q

describe Chrousos syndrome

A

primary generalized glucocorticoid resistance

issue with glucocorticoid receptor

rare and genetic

compesation: ^ACTH > HTN, K imbalances, hyperandrogenism

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3
Q

med to treat chrousos syndrome?

A

dexamethasone because of not Na retaining effects

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4
Q

how to treat aldosteronism?

A

spironolactone

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5
Q

where are mineralcorticoid receptors?

A

DCT and CD of kidney

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6
Q

where does mineralcorticoids cause Na retention?

A

sweat, salivary glands, GI mucosa
and kidney

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7
Q

what two things control aldosterone production?

A

50% ACTH
50% Angiotensin

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8
Q

how are mineral corticoids excreted?

A

conjugated tetrahydroaldosterone in the urine

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9
Q

what is endogenous precursor to aldosterone?

A

deoxycorticosterone

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10
Q

what primarily controls deoxycorticosterone secretion?

A

ACTH

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11
Q

can fludorocortisone bind both GR and MR?

A

yes

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12
Q

What non adrenal issues can glucocorticoids be used in?

A

allergic
GI
inflamatory
transplant
pulm

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13
Q

allergic uses of glucocorticoids?

A

angioneurotic edema, asthma, bee sting, contact dermatitis, drug reactions, allergic rhinitis, serum sickness, urticaria

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14
Q

GI uses of glucocorticoids?

A

inflammatory bowel disease, nontropical spruce (Celiac), subacute hepatic necrosis

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15
Q

anti-inflammatory uses of glucocorticoids?

A

in bones and joints
arthritis, bursitis, tensosynovitis

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16
Q

why would glucocorticoids be used in transplant?

A

immunosuppressive to decrease rejections

17
Q

pulm uses of glucocorticoids?

A

aspiration pneumonia, bronchial asthma, sarcoidosis, prevent infant resp distress syndrome,

18
Q

Adverse effects of estrogen therapy?

A

thromboembolism
MI
HTN
headache
edema
nausea

19
Q

3 kinds of adrenocortical antagonists?

A

steroid synthesis inhibitors
glucocorticoid antagonists
mineral corticoid antagonists

20
Q

what are the steroid synthesis inhibitors?

A

aminoglutethimide - cushings
ketoconazle - cushings
arbiraterone - for refractory prostate cancer

21
Q

Glucocorticoid antagonists?

A

Mifepristone (RV-486)
longer half life than steroids
extensive albumin binding

22
Q

why use Mifepristone (RV-486)?

A

ectopic ACTH secretion and adrenal cancer that failed other treatments

23
Q

Mineralcorticoid antagonists?

A

Spironolactone
Epleronone

24
Q

What to know about Spironolactone?

A

also an androgen antagonist
actions for 2-3 days after DC

25
Q

What to know about Epleronone?

A

more selective than Spiro
no androgen receptor effects

Pharmacology 1 Brandon's additional Cards (7 decks)

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