Endocrine Brandon Flashcards
How does somatropin compare to GH?
identical 191 amino acid sequence as GH
What hormone does somatropin resemble?
Prolactin
When does IGF-1 become dependent on GH?
during first year of life
When is IGF-1 essential?
prenatal and postnatal growth
adverse effects of mecasermin
hypoglycemia
intracranial HTN
adenotonsilar hypertrophy
elevated liver enzymes
What is rhIGFBP-3?
Mecasermin Rinfabate
GnRH Agonists?
Gonadorelin
Goserelin
Histrelin
Leuprolide
Nafareline
Triptorelin
hcG bind what receptors?
LH receptors
When to use GnRH antagonists?
endometriosis
prostate cancer
central precious puberty (early puberty)
breast & Ovarian Cancer
Which hormones act directly on target tissues?
POV
prolactin
oxytocin
vasopressin
S/S hyperprolactinemia in males?
loss of libido
infertility
s.s of hyperprolactinemia in females?
amenorrhea (no menstration)
galactorrhea (random nipple discharge)
how do antipsychotics affect prolactin levels?
they increase prolactin
What are the GnRH antagonists?
“relix”
Ganirelix
Cetrorelix
degarelix
Abarelix
cause dose dependent decrease of FSH/LH
What are ganirelix and cetrorelix used for?
ovarian hyperstimulation procedures
what are degarelix and abarelix used for?
advanced prostate cancer
extrarenal V2 receptors do what?
regulate factor VIII and von willebrand factor
Vasopression toxicity / CI
headache, NV, abd cramps, agitation (al masked by anesthesia)
overdose = hyponatremia > seizure
careful in pts with CAD
Vasopressin antagonists
Conivaptan
tolvaptan
conivaptan receptor affinity?
1:1 for V1:V2