Endocrine and Aging Flashcards Preview

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Flashcards in Endocrine and Aging Deck (14):
1

What happens to GH axis in aging?

Decrease in GH results in decrease in IGF-1 (somatopause)

2

What happens in HPG axis in aging?

Decline in LH/FSH leads to decrease in estrogen/tesosterone
(menopause/andropause)

3

What happens in HPA axis in aging?

Same amounts of ACTH and cortisol, but decreased DHEA response (adrenopause)

4

What are the four "pauses" of aging?

Menopause
Andropause
Adrenopause
Somatopause

5

Women's Health Initiative: What were results of chronic ERT?

Estrogen alone=no risk or benefit
Non-statistically significant reduction in colon cancer, hip fracture
No statistcaly signifiant increase in CHD, stroke, breast cancer, VTE

6

Dosing regimen for menopause ERT?

Give lowest possible dose for symptomatic relief then taper

7

What age-related changes occur in male sex hormones? Why?

Reduction in tesosterone due to attrition of leydig cells

8

When do you measure testosterone levels? Why

8AM-- levels highest in morning

9

How many men >40 receive androgen replacement therapy?

3%-- rates probably higher, and unnecessarily high due to marketing

10

How do growth hormone pulsatility change with aging?

Same frequency but lower amplitude

11

What hormone increases as you age? What disease does this have implications for?

Cortisol levels increase with age. This affects insulin sensitivity/resistance, having implications for DM

12

Which endocrine disease have different presentation with aging? What changes occur in elderly?

Hyperthyroidism and hypothyroidism has non-classical presentation in elderly.

Hyper: Increased apathy and anorexia
Hypo: Increased anorexia/weight loss

13

What changes occur in TSH levels in older populations?

Shift: older populations have on average higher TSH-- subclinical hypothyroidism

14

What thyroid-related change occurs in elderly despite apparent euthyroidism?

Atrial fibrillation, a sign of hyperthyroidism, increases even in patients with normal level TSH.