Endocrine Pharmacology(Ovary And Testis)

Question 1

What are the hormones of the ovary?

Answer 1

Oestrogen
Progesterone
Inhibin
Activin
Relaxin (responsible for growth.Inhibits Uterine Contraction)
Androgens

Question 2

What is the primary function of the androgens

Answer 2

Hair growth in Females

Question 3

Example of Androgens

Answer 3

Testosterone
Dehydroepiandrosterone
Androstenedione

Question 4

The change of ovarian function at puberty is called

Answer 4

Gonadarchy

Question 5

What cells of the follicles secrete estrogen under the influence of LH

Answer 5

Outer theca and inner granulosa

Question 6

Estrogen function reaches its peak when

Answer 6

Just before mid cycle

Question 7

The cavity of the ruptured follicle would be filled with blood known as

Answer 7

Corpus hemorrhagica

Question 8

In menopause, Estrogen production comes from

Answer 8

Conversion of adrenal and ovarian steroids such as androstenedione to estrone and estradiol

Question 9

Types of Estrogen

Answer 9

Natural Estrogen
Steroidal Synthetic Estrogen
Non steroidal Synthetic Estrogen

Question 10

Examples of natural Estrogen

Answer 10

Estradiol E2
Estrone E1
Estriol E3

Question 11

The major natural estrogen secreted by Women is

Answer 11

Estradiol

Question 12

Steroidal Synthetic Estrogen

Answer 12

Ethinyl estradiol
Mestranol
Quinestrol

Question 13

Non Steroidal Synthetic Estrogen

Answer 13

Diethylstibestrol
Dienestrol
Hexestrol
Benzestrol

Question 14

The Undesirable Side effect associated with the hepatic effect of Estrogen is

Answer 14

Increased Synthesis of clotting Factors

Question 15

What is the mech of action of estrogen

Answer 15

Binds to Intracellular estrogen receptors in the nucleus of a cell leading to protein synthesis

Question 16

The most important progestine in women is

Answer 16

Progesterone

Question 17

Progesterone is a ……… carbon compound

Answer 17

21

Question 18

Estrogen and testosterone are …………. and ………… carbon compounds respectively

Answer 18

18 and 19

Question 19

Progesterone serves as a precursor for

Answer 19

Estrogen
Androgen
Adrenocortical Steriods

Question 20

First gen progesterone

Answer 20

Norethisterone

Question 21

Second gen progesterone

Answer 21

Norgestrel
Levonorgestrel

Question 22

Third gen progesterone

Answer 22

Doxogestrel

Question 23

4th gen Progesterone

Answer 23

Drospirenone

Question 24

The third and fourth generation progesterone have less side effects because

Answer 24

They don’t have Androgens

Question 25

Therapeutic uses of Progesterone

Answer 25

Hormone replacement therapy Treatment of dysmenorrhea Treatment of Endometriosis

Question 26

In the use of Progesterone as a test of estrogen Secretion, what quantity and alternative drug is used

Answer 26

Progesterone 150mg/day Medroxyprogesterone acetate 10mg/day 5 to 7days

Question 27

The first selective estrogen receptor modulator

Answer 27

Tamoxifen

Question 28

Example of SERM(Selective Estrogen Receptor modulator) drugs are;

Answer 28

Tamoxifen Raloxifen

Question 29

Why is Raloxifene preferred to tamoxifen

Answer 29

It’s inability to cause Endometrial Cancer/hyperplasia

Question 30

Ovulation Induction agents

Answer 30

Clomiphene Citrate Letrozole/Anastrozole

Question 31

Mifepristone is used as an abortifacient when combined with

Answer 31

Misoprostol

Question 32

Progesterone receptor modulators used as Contraceptive

Answer 32

Ulipristal Mifepristone

Question 33

What produces testosterone and under the influence of what hormone

Answer 33

Leydig cells Luetinizing hormone

Question 34

Testosterone is bound majorly to…………. In the blood

Answer 34

Sex hormone binding globulin

Question 35

An estrogen inhibitor also a weak androgen used in the treatment of endometriosis

Answer 35

Danazol

Question 36

Infertility is

Answer 36

The Inability of a couple to achieve pregnancy after one year of regular, adequate and unprotected coitus

Question 37

Mech of Action of clomiphene citrate

Answer 37

Competitive Inhibitor of endogenous Estrogen…leading to increased gonadotrophin secretion

Question 38

Name the Fertility Drugs

Answer 38

Clomiphene citrate Letrozole/Anastrozole Metformin Dopamine agonist:bromocriptine Human Menopausal Gonadotropin

Question 39

Mech of action of Letrozole/Anastrozole

Answer 39

Irreversible inhibition of aromatase enzyme

Question 40

Where does metformin act as a fertility drug

Answer 40

In patients with PCOS…corrects the insulin insensitivity

Question 41

Menstropine…what is it?…where is it gotten from

Answer 41

Mixture of LH and FSH Urine of post menopausal women

Question 42

Two preparation for oral contraceptives are

Answer 42

COC- Combined Oral Contraceptive POP- Progesterone Only pill

Question 43

Combined Oral Contraceptive Example

Answer 43

Ethynl Estradiol

Question 44

Example of POP

Answer 44

Depotmedroxyprogesterone acetate(DMPA) Hormonal IUCD

Question 45

Why POP is preferred over COC

Answer 45

It has less side effects